Hallmarks of cancer: Tumor budding as a sign of invasion and metastasis in head and neck cancer

被引：48

作者：

Makitie, Antti A. ^{[1
,2
,3
,4
,5
]}

Almangush, Alhadi ^{[3
,6
,7
,8
]}

Rodrigo, Juan P. ^{[9
]}

Ferlito, Alfio ^{[10
]}

Leivo, Ilmo ^{[7
]}

机构：

[1] Univ Helsinki, Dept Otorhinolaryngol Head & Neck Surg, Helsinki, Finland

[2] Helsinki Univ Hosp, Helsinki, Finland

[3] Univ Helsinki, Res Program Syst Oncol, Fac Med, Helsinki, Finland

[4] Karolinska Inst, Dept Clin Sci Intervent & Technol, Div Ear Nose & Throat Dis, Stockholm, Sweden

[5] Karolinska Hosp, Stockholm, Sweden

[6] Univ Helsinki, Dept Pathol, Helsinki, Finland

[7] Univ Turku, Inst Biomed, Pathol, Turku, Finland

[8] Univ Misurata, Inst Dent, Misurata, Libya

[9] Univ Oviedo, Hosp Univ Cent Asturias, Dept Otolaryngol, ISPA,IUOPA,CIBERONC, Oviedo, Spain

[10] Int Head & Neck Sci Grp, Padua, Italy

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2019年 / 41卷 / 10期

关键词：

head and neck squamous cell carcinoma (HNSCC); invasion; metastasis; tumor budding; SQUAMOUS-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL-TRANSITION; LYMPH-NODE METASTASIS; INDEPENDENT PROGNOSTIC-FACTOR; MULTIVARIATE-ANALYSIS; COLORECTAL-CARCINOMA; POOR-PROGNOSIS; TONGUE; EXPRESSION; MARKER;

D O I：

10.1002/hed.25872

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Invasion and metastasis are hallmarks of cancer. The concept of tumor budding at tumor-host interface has been documented in many carcinomas. A growing body of evidence indicates that tumor budding is a sign of invasion and early step for metastasis of many epithelial cancers including head and neck squamous cell carcinoma (HNSCC). In addition, recent research has underlined the importance of tumor budding as a promising prognosticator in HNSCC. This review summarizes the findings regarding tumor budding in HNSCC and focuses on the role of tumor budding in invasion and metastasis. Also, we highlight the prognostic significance of tumor budding in HNSCC and its potential for improving clinical decision making in terms of recommending optimal individualized treatment for this patient population.

引用

页码：3712 / 3718

页数：7

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