Organ-on-chip to investigate host-pathogens interactions

被引：21

作者：

Feaugas, Thomas ^{[1
]}

Sauvonnet, Nathalie ^{[1
]}

机构：

[1] Inst Pasteur, Grp Intracellular Trafficking & Tissue Homeostasi, 28 Rue Dr Roux, F-75015 Paris, France

来源：

CELLULAR MICROBIOLOGY | 2021年 / 23卷 / 07期

关键词：

bacteria; mechanical forces; microbiota; microfluidic; organ‐ on‐ chip; virus;

D O I：

10.1111/cmi.13336

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Infectious diseases remain the subject of intense research. This topic reaches a new era towards the study of host-pathogen interactions mechanisms at the tissue scale. The past few years have hence witnessed the emergence of new methods. Among them, organ-on-chip, which combines biomaterial technology, microfluidic and tissue engineering to recreate the organ physiology is very promising. This review summarises how this technology recapitulates the architecture, the mechanical stimulation and the interface of a tissue and how this particular microenvironment is critical to study host-pathogen interactions.

引用

页数：9

共 56 条

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