Synthesis and application of bulky phosphoramidites: highly effective monophosphorus ligands for asymmetric hydrosilylation of styrenes

被引：24

作者：

Zhang, Feng ^{[1
]}

Fan, Qing-Hua ^{[1
]}

机构：

[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 21期

基金：

中国国家自然科学基金;

关键词：

PALLADIUM-CATALYZED HYDROSILYLATION; MONODENTATE PHOSPHORUS LIGANDS; ENANTIOSELECTIVE HYDROGENATION; PHOSPHINE LIGAND; COMPLEXES; OLEFINS; MOP;

D O I：

10.1039/b909334f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of bulky monodentate phosphoramidite ligands were synthesized from chiral 3,3'-diaryl substituted BINOL derivatives and achiral or dendritic amines in good yields. Asymmetric hydrosilylation of styrenes with trichlorosilane in the presence of palladium complexes of these bulky ligands gave chiral silanes in high yields with excellent activity and productivity. Oxidation of these chiral silanes with hydrogen peroxide gave the corresponding chiral secondary alcohols in up to 96% ee.

引用

页码：4470 / 4474

页数：5

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