Synthetic applications of α,α-difluoroarylacetic acids and salts via decarboxylative functionalization

被引：22

作者：

Mei, Wenqiang ^{[1
]}

Kong, Yilin ^{[1
]}

Yan, Guobing ^{[1
]}

机构：

[1] Zhejiang A&F Univ, Coll Jiyang, Zhuji 311800, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2021年 / 8卷 / 19期

关键词：

ALIPHATIC CARBOXYLIC-ACIDS; C-H FUNCTIONALIZATION; O BOND FORMATION; CATALYZED DIFLUOROALKYLATION; OXIDATIVE DECARBOXYLATION; PHOTOREDOX CATALYSIS; UNACTIVATED ALKENES; ALKYNYLATION; FLUORINATION; CHEMISTRY;

D O I：

10.1039/d1qo00775k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha,alpha-Difluoroarylacetic acids are stable, inexpensive and readily available building blocks, which have been recently utilized as synthons to access various difluoromethylated aryl motifs via decarboxylative functionalization, such as alkylation, allylation, alkynylation, arylation, fluorination and the formation of carbon-heteroatom (O, S) bonds. In this review, we systematically summarize the decarboxylative functionalization of alpha,alpha-difluoroarylacetic acids and salts, and their mechanisms are also discussed.

引用

页码：5516 / 5530

页数：15

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