Scaffold Diversity from N-Acyliminium Ions

被引：174

作者：

Wu, Peng ^{[1
,2
,3
,4
,5
,6
]}

Nielsen, Thomas E. ^{[1
,2
,7
]}

机构：

[1] Tech Univ Denmark, Dept Chem, DK-2800 Kongens Lyngby, Denmark

[2] Univ Copenhagen, Dept Immunol & Microbiol, DK-2200 Copenhagen, Denmark

[3] Broad Inst MIT & Harvard, Ctr Sci Therapeut, Cambridge, MA 02142 USA

[4] Harvard Med Sch, Dept Med, Boston, MA 02115 USA

[5] Brigham & Womens Hosp, Div Renal, Boston, MA 02115 USA

[6] MIT, Dept Chem, Cambridge, MA 02139 USA

[7] Nanyang Technol Univ, Singapore Ctr Environm Life Sci Engn, Singapore 637551, Singapore

来源：

CHEMICAL REVIEWS | 2017年 / 117卷 / 12期

关键词：

INTRAMOLECULAR SCHMIDT REACTION; DIRECT IMINE ACYLATION; INTERMOLECULAR ADDITION-REACTIONS; ALPHA-AMIDOALKYLATION REACTIONS; QUATERNARY CARBON STEREOCENTER; DYNAMIC KINETIC RESOLUTION; ASYMMETRIC TOTAL-SYNTHESIS; PICTET-SPENGLER REACTIONS; STEREOSELECTIVE-SYNTHESIS; CYCLIZATION REACTIONS;

D O I：

10.1021/acs.chemrev.6b00806

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

N-Acyliminium ions are powerful reactive species for the formation of carbon carbon and carbon-heteroatom bonds. Strategies relying on intramolecular reactions of N-acyliminium intermediates, also referred to as N-acyliminium ion cyclization reactions, have been employed for the construction of structurally diverse scaffolds, ranging from simple bicyclic skeletons to complex polycyclic systems and natural-product-like compounds. This review aims to provide an overview of cyclization reactions of N-acyliminium ions derived from various precursors for the assembly of structurally diverse scaffolds, covering the literature over the past 12 years (from 2004 to 2015).

引用

页码：7811 / 7856

页数：46

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