Inflammatory Molecules Associated with Ultraviolet Radiation-Mediated Skin Aging

被引：245

作者：

Ansary, Tuba M. ^{[1
]}

Hossain, Md. Razib ^{[1
]}

Kamiya, Koji ^{[1
]}

Komine, Mayumi ^{[1
]}

Ohtsuki, Mamitaro ^{[1
]}

机构：

[1] Jichi Med Univ, Fac Med, Dept Dermatol, Shimotsuke, Tochigi 3290498, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 08期

基金：

日本学术振兴会;

关键词：

inflammation; ultraviolet radiation (UVR); skin aging;

D O I：

10.3390/ijms22083974

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Skin is the largest and most complex organ in the human body comprised of multiple layers with different types of cells. Different kinds of environmental stressors, for example, ultraviolet radiation (UVR), temperature, air pollutants, smoking, and diet, accelerate skin aging by stimulating inflammatory molecules. Skin aging caused by UVR is characterized by loss of elasticity, fine lines, wrinkles, reduced epidermal and dermal components, increased epidermal permeability, delayed wound healing, and approximately 90% of skin aging. These external factors can cause aging through reactive oxygen species (ROS)-mediated inflammation, as well as aged skin is a source of circulatory inflammatory molecules which accelerate skin aging and cause aging-related diseases. This review article focuses on the inflammatory pathways associated with UVR-mediated skin aging.

引用

页数：14

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