Current and future therapies for advanced pancreatic cancer

被引：150

作者：

Gupta, Rohan ^{[1
]}

Amanam, Idoroenyi ^{[1
]}

Chung, Vincent ^{[1
]}

机构：

[1] City Hope Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 USA

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2017年 / 116卷 / 01期

关键词：

cytotoxic chemotherapy; pancreas cancer; vaccine therapy; TISSUE GROWTH-FACTOR; T-CELL IMMUNITY; STELLATE CELLS; NAB-PACLITAXEL; TGF-BETA; SPARC EXPRESSION; INDOLEAMINE 2,3-DIOXYGENASE; DESMOPLASTIC REACTION; ENZYMATIC DEPLETION; ANTITUMOR-ACTIVITY;

D O I：

10.1002/jso.24623

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic cancer remains a deadly disease with a 5-year survival rate of only 8%. Even after surgical resection, most patients have recurrence of their cancer. Over the last 10 years, improvements in chemotherapy regimens led to a doubling in median overall survival. Here we review the management of advanced pancreatic cancer and highlight vaccine therapy as a novel modality of treatment.

引用

页码：25 / 34

页数：10

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