Characteristics and Outcomes of COVID-19 in Patients on Left Ventricular Assist Device Support

被引：23

作者：

Birati, Edo Y. ^{[1
,2
,3
,7
]}

Najjar, Samer S. ^{[6
]}

Tedford, Ryan J. ^{[8
]}

Houston, Brian A. ^{[8
]}

Shore, Supriya ^{[9
]}

Vorovich, Esther ^{[10
]}

Atluri, Pavan ^{[4
]}

Urgo, Kimberly ^{[1
]}

Molina, Maria ^{[1
]}

Chambers, Susan ^{[1
]}

Escobar, Nicole ^{[1
]}

Hsich, Eileen ^{[11
,12
]}

Estep, Jerry D. ^{[11
,12
]}

Alexander, Kevin M. ^{[13
,14
]}

Teuteberg, Jeffrey J. ^{[13
,14
]}

Chaudhry, Sunit-Preet ^{[15
]}

Ravichandran, Ashwin ^{[15
]}

DeVore, Adam D. ^{[16
,17
]}

Margulies, Kenneth B. ^{[1
]}

Hanff, Thomas C. ^{[1
]}

Zimmer, Ross ^{[1
]}

Kilic, Arman ^{[18
]}

Wald, Joyce W. ^{[1
]}

Vidula, Himabindu ^{[19
]}

Martens, John ^{[19
]}

Blumberg, Emily A. ^{[5
]}

Mazurek, Jeremy A. ^{[1
]}

Owens, Anjali T. ^{[1
]}

Goldberg, Lee R. ^{[1
]}

Alvarez-Garcia, Jesus ^{[20
]}

Mancini, Donna M. ^{[20
]}

Moss, Noah ^{[20
]}

Genuardi, Michael, V ^{[1
]}

机构：

[1] Univ Penn, Dept Med, Cardiovasc Div, Philadelphia, PA 19104 USA

[2] Univ Penn, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Univ Penn, Cardiovasc Outcomes Qual & Evaluat Res Ctr, Philadelphia, PA 19104 USA

[4] Univ Penn, Dept Cardiothorac Surg, Philadelphia, PA 19104 USA

[5] Univ Penn, Div Infect Dis, Philadelphia, PA 19104 USA

[6] MedStar Washington Hosp Ctr, Washington, DC USA

[7] Bar Ilan Univ, Poriya Med Ctr, Cardiovasc Div, Ramat Gan, Israel

[8] Med Univ South Carolina, Charleston, SC 29425 USA

[9] Univ Michigan, Cardiovasc Div, Ann Arbor, MI 48109 USA

[10] Northwestern Univ, Div Cardiol, Chicago, IL 60611 USA

[11] Case Western Reserve Univ, Heart & Vasc Inst, Cleveland Clin, Sch Med, Cleveland, OH 44106 USA

[12] Case Western Reserve Univ, Cleveland Clin, Lerner Coll Med, Sch Med, Cleveland, OH 44106 USA

[13] Stanford Univ, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA

[14] Stanford Univ, Stanford Cardiovasc Inst, Sch Med, Stanford, CA 94305 USA

[15] St Vincent Heart Ctr, St Vincent Med Grp, Indianapolis, IN USA

[16] Duke Univ, Sch Med, Duke Clin Res Inst, Durham, NC USA

[17] Duke Univ, Sch Med, Dept Med, Durham, NC 27706 USA

[18] Univ Pittsburgh, Med Ctr, Div Cardiac Surg, Pittsburgh, PA 15260 USA

[19] Univ Rochester, Div Cardiol, Sch Med & Dent, Rochester, NY 14627 USA

[20] Icahn Sch Med Mt Sinai, Zena & Michael Wiener Cardiovasc Inst, New York, NY 10029 USA

来源：

CIRCULATION-HEART FAILURE | 2021年 / 14卷 / 04期

关键词：

COVID-19; heart failure; hospitalization; outcomes research; SARS-CoV-2; ventricular assist device;

D O I：

10.1161/CIRCHEARTFAILURE.120.007957

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The coronavirus disease 2019 (COVID-19) pandemic continues to afflict millions of people worldwide. Patients with end-stage heart failure and left ventricular assist devices (LVADs) may be at risk for severe COVID-19 given a high prevalence of complex comorbidities and functional impaired immunity. The objective of this study is to describe the clinical characteristics and outcomes of COVID-19 in patients with end-stage heart failure and durable LVADs. Methods: The Trans-CoV-VAD registry is a multi-center registry of LVAD and cardiac transplant patients in the United States with confirmed COVID-19. Patient characteristics, exposure history, presentation, laboratory data, course, and clinical outcomes were collected by participating institutions and reviewed by a central data repository. This report represents the participation of the first 9 centers to report LVAD data into the registry. Results: A total of 40 patients were included in this cohort. The median age was 56 years (interquartile range, 46-68), 14 (35%) were women, and 21 (52%) were Black. Among the most common presenting symptoms were cough (41%), fever, and fatigue (both 38%). A total of 18% were asymptomatic at diagnosis. Only 43% of the patients reported either subjective or measured fever during the entire course of illness. Over half (60%) required hospitalization, and 8 patients (20%) died, often after lengthy hospitalizations. Conclusions: We present the largest case series of LVAD patients with COVID-19 to date. Understanding these characteristics is essential in an effort to improve the outcome of this complex patient population.

引用

页数：9

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