Traces of human migrations in Helicobacter pylori populations

被引：732

作者：

Falush, D

Wirth, T

Linz, B

Pritchard, JK

Stephens, M

Kidd, M

Blaser, MJ

Graham, DY

Vacher, S

Perez-Perez, GI

Yamaoka, Y

Mégraud, F

Otto, K

Reichard, U

Katzowitsch, E

Wang, XY

Achtman, M ^{[1
]}

Suerbaum, S

机构：

[1] Max Planck Inst Infekt Biol, Dept Mol Biol, D-10117 Berlin, Germany

[2] Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA

[3] Univ Washington, Dept Stat, Seattle, WA 98195 USA

[4] Yale Univ, Sch Med, Dept Surg, New Haven, CT 06520 USA

[5] NYU, Sch Med, Dept Med, New York, NY 10016 USA

[6] Vet Affairs Med Ctr, Houston, TX 77030 USA

[7] Univ Bordeaux 2, F-33076 Bordeaux, France

[8] Univ Wurzburg, Inst Hyg & Mikrobiol, D-97080 Wurzburg, Germany

来源：

SCIENCE | 2003年 / 299卷 / 5612期

关键词：

D O I：

10.1126/science.1080857

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Helicobacter pylori, a chronic gastric pathogen of human beings, can be divided into seven populations and subpopulations with distinct geographical distributions. These modern populations derive their gene pools from ancestral populations that arose in Africa, Central Asia, and East Asia. Subsequent spread can be attributed to human migratory fluxes such as the prehistoric colonization of Polynesia and the Americas, the neolithic introduction of farming to Europe, the Bantu expansion within Africa, and the stave trade.

引用

页码：1582 / 1585

页数：4

共 25 条

[1] Recombination and clonal groupings within Helicobacter pylori from different geographical regions [J].