Small-Field Measurements of 3D Polymer Gel Dosimeters through Optical Computed Tomography

被引：17

作者：

Shih, Tian-Yu ^{[1
,2
,3
]}

Wu, Jay ^{[4
]}

Shih, Cheng-Ting ^{[5
]}

Lee, Yao-Ting ^{[2
]}

Wu, Shin-Hua ^{[3
]}

Yao, Chun-Hsu ^{[1
,6
,7
]}

Hsieh, Bor-Tsung ^{[2
]}

机构：

[1] China Med Univ, Grad Inst Clin Med Sci, Taichung, Taiwan

[2] Cent Taiwan Univ Sci & Technol, Dept Med Imaging & Radiol Sci, Taichung, Taiwan

[3] Cheng Ching Hosp Chung Kang, Dept Radiol, Taichung, Taiwan

[4] Natl Yang Ming Univ, Dept Biomed Imaging & Radiol Sci, Taipei 112, Taiwan

[5] China Med Univ Hosp, Printing Med Res Ctr 3D, Taichung, Taiwan

[6] China Med Univ, Coll Hlth Care, Dept Biomed Imaging & Radiol Sci, Taichung, Taiwan

[7] Asia Univ, Dept Biomed Informat, Taichung, Taiwan

来源：

PLOS ONE | 2016年 / 11卷 / 03期

关键词：

RADIATION-DOSE DISTRIBUTIONS; NMR;

D O I：

10.1371/journal.pone.0151300

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

With advances in therapeutic instruments and techniques, three-dimensional dose delivery has been widely used in radiotherapy. The verification of dose distribution in a small field becomes critical because of the obvious dose gradient within the field. The study investigates the dose distributions of various field sizes by using NIPAM polymer gel dosimeter. The dosimeter consists of 5% gelatin, 5% monomers, 3% cross linkers, and 5 mM THPC. After irradiation, a 24 to 96 hour delay was applied, and the gel dosimeters were read by a cone beam optical computed tomography (optical CT) scanner. The dose distributions measured by the NIPAM gel dosimeter were compared to the outputs of the treatment planning system using gamma evaluation. For the criteria of 3%/3 mm, the pass rates for 5 x 5, 3 x 3, 2 x 2, 1 x 1, and 0.5 x 0.5 cm(2) were as high as 91.7%, 90.7%, 88.2%, 74.8%, and 37.3%, respectively. For the criteria of 5%/5 mm, the gamma pass rates of the 5 x 5, 3 x 3, and 2 x 2 cm2 fields were over 99%. The NIPAM gel dosimeter provides high chemical stability. With cone-beam optical CT readouts, the NIPAM polymer gel dosimeter has potential for clinical dose verification of small-field irradiation.

引用

页数：15