Hyperglycemia aggravates acute liver injury by promoting macrophage NLRP3 activation via AMPK/mTOR-dependent autophagy inhibition

被引：0
|
作者：
Zhou, H. [1 ]
Wang, Q. [1 ]
Liu, R. [1 ]
Zhou, S. [1 ]
Shi, C. [1 ]
Wei, S. [1 ]
Rao, Z. [1 ]
Cheng, F. [1 ]
Wang, X. [1 ]
Lyu, L. [1 ]
机构：
[1] Nanjing Med Univ, Affiliated Hosp 1, Liver Transplant Ctr, Nanjing, Jiangsu, Peoples R China
来源：
TRANSPLANTATION | 2019年 / 103卷 / 08期
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
P-348
引用
收藏
页码：267 / 268
页数：2
相关论文
共 50 条
  • [21] Palmatine attenuates hepatocyte injury by promoting autophagy via the AMPK/mTOR pathway after alcoholic liver disease
    Lin, Guo-Shuai
    Zhao, Mao-Mao
    Fu, Qi-Chao
    Zhao, Shu-Yi
    Ba, Tao-Tao
    Yu, Hong-Xia
    DRUG DEVELOPMENT RESEARCH, 2022, 83 (07) : 1613 - 1622
  • [22] miR-99a-5p: A Potential New Therapy for Atherosclerosis by Targeting mTOR and Then Inhibiting NLRP3 Inflammasome Activation and Promoting Macrophage Autophagy
    Wang, Gang
    Jing, Shu-Yan
    Liu, Gang
    Guo, Xue-Jia
    Zhao, Wei
    Jia, Xin-Le
    Zheng, Ming-Qi
    Tan, Wen-Yun
    DISEASE MARKERS, 2022, 2022
  • [23] miR-99a-5p: A Potential New Therapy for Atherosclerosis by Targeting mTOR and Then Inhibiting NLRP3 Inflammasome Activation and Promoting Macrophage Autophagy
    Wang, Gang
    Jing, Shu-Yan
    Liu, Gang
    Guo, Xue-Jia
    Zhao, Wei
    Jia, Xin-Le
    Zheng, Ming-Qi
    Tan, Wen-Yun
    DISEASE MARKERS, 2022, 2022
  • [24] Fine particulate matter exposure aggravates ischemic injury via NLRP3 inflammasome activation and pyroptosis
    Gao, Li
    Qin, Jie-Xing
    Shi, Jian-Quan
    Jiang, Teng
    Wang, Fei
    Xie, Chong
    Gao, Qing
    Zhi, Nan
    Dong, Qing
    Guan, Yang-Tai
    CNS NEUROSCIENCE & THERAPEUTICS, 2022, 28 (07) : 1045 - 1058
  • [25] 6-Paradol alleviates Diclofenac-induced acute kidney injury via autophagy enhancement-mediated by AMPK/AKT/mTOR and NLRP3 inflammasome pathways
    El-Maadawy, Walaa H.
    Hassan, Marwa
    Abdou, Rabab M.
    El-Dine, Riham S.
    Aboushousha, Tarek
    El-Tanbouly, Nebal D.
    El-Sayed, Aly M.
    ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY, 2022, 91
  • [26] Autophagy Induced by Micheliolide Alleviates Acute Irradiation-Induced Intestinal Injury via Inhibition of the NLRP3 Inflammasome
    Wu, Dong-ming
    Li, Jing
    Shen, Rong
    Li, Jin
    Yu, Ye
    Li, Li
    Deng, Shi-hua
    Liu, Teng
    Zhang, Ting
    Xu, Ying
    Wang, De-gui
    FRONTIERS IN PHARMACOLOGY, 2022, 12
  • [27] Saikosaponin A inhibits the activation of pancreatic stellate cells by suppressing autophagy and the NLRP3 inflammasome via the AMPK/mTOR pathway (vol 128, 110216, 2020)
    Cui, Lihua
    Li, Caixia
    Zhuo, Yuzhen
    Yang, Lei
    Cui, Naiqiang
    Li, Yuhong
    Zhang, Shukun
    BIOMEDICINE & PHARMACOTHERAPY, 2020, 130
  • [28] Diabetes aggravates acute pancreatitis possibly via activation of NLRP3 inflammasome in db/db mice
    Gao, Lin
    Lu, Guo-Tao
    Lu, Ying-Ying
    Xiao, Wei-Ming
    Mao, Wen-Jian
    Tong, Zhi-Hui
    Yang, Na
    Li, Bai-Qia Ng
    Yang, Qi
    Ding, Yan-Bing
    Li, Wei-Qin
    AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2018, 10 (07): : 2015 - 2025
  • [29] Kir6.2 knockout aggravates lipopolysaccharide-induced mouse liver injury via enhancing NLRP3 inflammasome activation
    Du, Ren-Hong
    Tan, Jun
    Yan, Nan
    Wang, Ling
    Qiao, Chen
    Ding, Jian-Hua
    Lu, Ming
    Hu, Gang
    JOURNAL OF GASTROENTEROLOGY, 2014, 49 (04) : 727 - 736
  • [30] Transcriptional enhancement of GBP-5 by BATF aggravates sepsis-associated liver injury via NLRP3 inflammasome activation
    Guo, Hongli
    Ni, Mingming
    Xu, Jing
    Chen, Feng
    Yao, Zhaoying
    Yao, Yiqin
    Liu, Chao
    Du, Qianming
    FASEB JOURNAL, 2021, 35 (06):
12345