The DAPA-HF Trial: A Momentous Victory in the War against Heart Failure

被引：42

作者：

Bhatt, Deepak L. ^{[1
]}

Verma, Subodh ^{[2
]}

Braunwald, Eugene ^{[1
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 USA

[2] Univ Toronto, Li Ka Shing Knowledge Inst, St Michaels Hosp, Dept Surg,Div Cardiac Surg, Toronto, ON, Canada

来源：

CELL METABOLISM | 2019年 / 30卷 / 05期

关键词：

D O I：

10.1016/j.cmet.2019.10.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In a randomized trial of patients with heart failure and reduced ejection fraction, the SGLT2 inhibitor dapagliflozin markedly reduced mortality and worsening heart failure (McMurray et al., 2019). Remarkably, these benefits seemed to be similar in people with and without diabetes. These data usher in a new paradigm in the treatment of heart failure.

引用

页码：847 / 849

页数：3

共 13 条

[1] The war against heart failure: the Lancet lecture [J].

Braunwald, Eugene .

LANCET, 2015, 385 (9970) :812-824

[2]

Byrne Nikole J, 2017, JACC Basic Transl Sci, V2, P347, DOI 10.1016/j.jacbts.2017.07.003

[3] Empagliflozin Improves Diastolic Function in a Nondiabetic Rodent Model of Heart Failure With Preserved Ejection Fraction [J].

Connelly, Kim A. ;

Zhang, Yanling ;

Visram, Aylin ;

Advani, Andrew ;

Batchu, Sri N. ;

Desjardins, Jean-Francois ;

Thai, Kerri ;

Gilbert, Richard E. .

JACC-BASIC TO TRANSLATIONAL SCIENCE, 2019, 4 (01) :27-37

[4] Can We DECLARE a Victory against Cardio-Renal Disease in Diabetes? [J].

Connelly, Kim A. ;

Bhatt, Deepak L. ;

Verma, Subodh .

CELL METABOLISM, 2018, 28 (06) :813-815

[5] SGLT2 Inhibition with Empagliflozin Increases Circulating Provascular Progenitor Cells in People with Type 2 Diabetes Mellitus [J].

Hess, David A. ;

Terenzi, Daniella C. ;

Trac, Justin Z. ;

Quan, Adrian ;

Mason, Tamique ;

Al-Omran, Mohammed ;

Bhatt, Deepak L. ;

Dhingra, Natasha ;

Rotstein, Ori D. ;

Leiter, Lawrence A. ;

Zinman, Bernard ;

Sabongui, Sandra ;

Yan, Andrew T. ;

Teoh, Hwee ;

Mazer, C. David ;

Connelly, Kim A. ;

Verma, Subodh .

CELL METABOLISM, 2019, 30 (04) :609-613

[6] Empagliflozin's Fuel Hypothesis: Not so Soon [J].

Lopaschuk, Gary D. ;

Verma, Subodh .

CELL METABOLISM, 2016, 24 (02) :200-202

[7] Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction [J].

McMurray, J. J. V. ;

Solomon, S. D. ;

Inzucchi, S. E. ;

Kober, L. ;

Kosiborod, M. N. ;

Martinez, F. A. ;

Ponikowski, P. ;

Sabatine, M. S. ;

Anand, I. S. ;

Belohlavek, J. ;

Bohm, M. ;

Chiang, C. -E. ;

Chopra, V. K. ;

de Boer, R. A. ;

Desai, A. S. ;

Diez, M. ;

Drozdz, J. ;

Dukat, A. ;

Ge, J. ;

Howlett, J. G. ;

Katova, T. ;

Kitakaze, M. ;

Ljungman, C. E. A. ;

Merkely, B. ;

Nicolau, J. C. ;

O'Meara, E. ;

Petrie, M. C. ;

Vinh, P. N. ;

Schou, M. ;

Tereshchenko, S. ;

Verma, S. ;

Held, C. ;

DeMets, D. L. ;

Docherty, K. F. ;

Jhund, P. S. ;

Bengtsson, O. ;

Sjostrand, M. ;

Langkilde, A. -M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (21) :1995-2008

[8] Saxagliptin and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus [J].

Scirica, Benjamin M. ;

Bhatt, Deepak L. ;

Braunwald, Eugene ;

Steg, P. Gabriel ;

Davidson, Jaime ;

Hirshberg, Boaz ;

Ohman, Peter ;

Frederich, Robert ;

Wiviott, Stephen D. ;

Hoffman, Elaine B. ;

Cavender, Matthew A. ;

Udell, Jacob A. ;

Desai, Nihar R. ;

Mosenzon, Ofri ;

McGuire, Darren K. ;

Ray, Kausik K. ;

Leiter, Lawrence A. ;

Raz, Itamar ;

Braunwald, Eugene ;

Bhatt, Deepak L. ;

Scirica, Benjamin M. ;

Udell, Jacob A. ;

Cavender, Matthew A. ;

Desai, Nihar ;

Abrahamsen, Timothy ;

Grossman, Michelle ;

Morin, Suzanne ;

Im, Kyungah ;

Hoffman, Elaine ;

Gabovitch, Daniel ;

Pricken, Alexandra ;

Mosenzon, Ofri ;

Buskila, Alona ;

Ohman, Peter ;

Hirshberg, Boaz ;

Stahre, Christina ;

Price, Deborah ;

Billing-Clason, Solveig ;

Sabel, Karin ;

Monyak, John ;

Sjostrand, Mikalea ;

Wei, Cheryl ;

Lu, Jane ;

Miller, Elinor ;

Raichlen, Joel ;

Fitt, Sandy ;

Frederich, Robert ;

Iqbal, Nayyar ;

Donovan, Mark ;

Davidson, Jaime A. .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (14) :1317-1326

[9]

Verma S., 2019, CIRCULATION, DOI [10.1161/CIRCULATIONAHA.1119.042375, DOI 10.1161/CIRCULATIONAHA.1119.042375]

[10]

Verma Subodh, 2018, JACC Basic Transl Sci, V3, P575, DOI 10.1016/j.jacbts.2018.07.006

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