Rare Association of Coeliac Disease with Aplastic Anaemia: Report of a Case from India

被引:5
作者
Basu, Ayan [1 ]
Ray, Yogiraj [1 ]
Bowmik, Pratik [1 ]
Rahman, Mehebubar [1 ]
Dikshit, Nidhi [2 ]
Goswami, Rama Prosad [1 ,2 ]
机构
[1] Calcutta Sch Trop Med, Dept Trop Med, Kolkata, India
[2] Calcutta Sch Trop Med, Dept Haematol, Kolkata, India
关键词
Coeliac disease; Aplastic Anaemia; India;
D O I
10.1007/s12288-014-0331-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Coeliac disease is a systemic autoimmune disorder with major intestinal manifestations. It has multiple hematologic associations including anaemia (mostly due to iron, folate and/or vitamin B12 malabsorption), other cytopenias, coagulation abnormalities, hyposplenism, IgA deficiency and lymphomas. Aplastic anaemia has however, only rarely been described with celiac disease in published literature. We here present a case of atypical coeliac disease in a 40 year male Indian patient, with insignificant gastrointestinal symptoms, presenting with aplastic anaemia manifested by pancytopenia with hypocellular bone marrow. On gluten free diet, his symptoms like weakness, fatigue and malaise were relieved-blood and platelet transfusion requirement also diminished.
引用
收藏
页码:S208 / S211
页数:4
相关论文
共 8 条
[1]   Hematologic manifestation of childhood celiac disease [J].
Fisgin, T ;
Yarali, N ;
Duru, F ;
Usta, B ;
Kara, A .
ACTA HAEMATOLOGICA, 2004, 111 (04) :211-214
[2]   Medical progress: Celiac disease [J].
Green, Peter H. R. ;
Cellier, Christophe .
NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (17) :1731-1743
[3]   Aplastic anaemia in association with coeliac disease: a series of three cases [J].
Grey-Davies, E. ;
Hows, J. M. ;
Marsh, J. C. W. .
BRITISH JOURNAL OF HAEMATOLOGY, 2008, 143 (02) :258-260
[4]   Hematologic manifestations of celiac disease [J].
Halfdanarson, Thorvardur R. ;
Litzow, Mark R. ;
Murray, Joseph A. .
BLOOD, 2007, 109 (02) :412-421
[5]  
Lal S, 2005, INDIAN J GASTROEN S1, V24, pA39
[6]   Changing presentation of adult celiac disease [J].
Lo, WS ;
Sano, K ;
Lebwohl, B ;
Diamond, B ;
Green, PHR .
DIGESTIVE DISEASES AND SCIENCES, 2003, 48 (02) :395-398
[7]   Association of Celiac Disease with Aplastic Anemia [J].
Maheshwari, Anu ;
Nirupam, Nilay ;
Aneja, Satinder ;
Meena, Rajesh ;
Chandra, Jagdish ;
Kumar, Praveen .
INDIAN JOURNAL OF PEDIATRICS, 2012, 79 (10) :1372-1373
[8]   Coeliac disease and aplastic anaemia: a specific entity? [J].
Salmeron, Geraldine ;
Patey, Natacha ;
de Latour, Regis Peffault ;
Raffoux, Emmanuel ;
Gluckman, Eliane ;
Brousse, Nicole ;
Socie, Gerard ;
Robin, Marie .
BRITISH JOURNAL OF HAEMATOLOGY, 2009, 146 (01) :122-124