How Hydra senses and destroys microbes

被引：43
作者：
Augustin, Rene [1 ]
Fraune, Sebastian [1 ]
Bosch, Thomas C. G. [1 ]
机构：
[1] Univ Kiel, Inst Zool, D-24098 Kiel, Germany
来源：
SEMINARS IN IMMUNOLOGY | 2010年 / 22卷 / 01期
关键词：
Hydra; Innate immunity; Epithelial defence; Toll-like receptors; Antimicrobial peptides; Orphan genes; Bacterial microbiota; INNATE IMMUNITY; METAZOAN HYDRA; CAENORHABDITIS-ELEGANS; ANCESTRAL COMPLEXITY; EVOLUTION; SYSTEM; INVERTEBRATES; MAINTENANCE; CNIDARIANS; DEFENSE;
D O I：
10.1016/j.smim.2009.11.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Molecular genetic evidence has revealed that the basic templates of innate immune sensors were laid down in ancient animals such as the cnidarian Hydra. Important functions of Hydra's innate immune sensors and effectors include not only protection against pathogens but also controlling tissue-microbiota homeostasis. The deep evolutionary connections imply that invertebrate and mammalian immune pathways have evolved from a reduced number of common ancestral building blocks to their present configurations. (C) 2009 Elsevier Ltd. All rights reserved.
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收藏
页码：54 / 58
页数：5
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