Renal dysfunction is the most important predictor of the extent and severity of coronary artery disease in patients with diabetes mellitus

Objectives Diabetic patients tend to have more extensive and diffuse coronary artery disease (CAD) that may contribute to the less favorable outcomes in them. The aim of this study was to elucidate the predictors of the angiographic severity and extent of CAD in patients with diabetes. Methods A total of 203 diabetic patients (1116 men; mean age, 61.9 +/- 10.8) who were referred for a first coronary angiogram were included. The extent and severity of CAD was assessed in several ways. The first was a simple classification in one-vessel, two-vessel, and three-vessel disease scoring system. The total numbers of segments with >= 20 and >= 50% stenosis were calculated as CASS 20 and CASS 50 scores, respectively. Hamsten and Gensini scores were also calculated. Results Of the 203 patients included in the study, 175 (86.2%) had CAD. Multivariate ordinal logistic regression analysis showed that age (Wald 5.741, P=0.017), glomerular filtration rate (Wald 5.032, P=0.025), previous myocardial infarction (Wald 10.955, P=0.001), and family history of CAD (Wald 7.236, P=0.007) were independent predictors of the severity of CAD, as assessed by the clinical zero-vessel to three-vessel disease scoring system. On stepwise multiple linear regression analysis, glomerular filtration rate was an independent predictor of the CASS 20 (r=-0.221, P=0.004), CASS 50 (r=-0.239, P=0.005), Gensini (r=-0.328, P < 0.001), and Hamsten (r=-0.320, P < 0.001) scores. Previous myocardial infarction was an independent predictor of the CASS 50 (r=0.355, P < 0.001), Gensini (r=0.350, P < 0.001), and Hamsten (0.256, P < 0.001) scores. Age and sex were independent predictors for the CASS 50 (r= 0.174, P= 0.039; r= 0.172, P= 0.016, respectively) and Hamsten (r= 0.212, P= 0.011; r=0.244, P=0.001, respectively) scores. Conclusion Renal function is one of the most important factors associated with the extent and severity of coronary atherosclerosis, whereas classical coronary risk factors and the degree of metabolic control were not associated with the severity of coronary atherosclerosis in diabetic patients. Coron Artery Dis 18:463-469 (c) 2007 Lippincott Williams & Wilkins.