Acute encephalitis, myoclonus and Sweet syndrome after mRNA-1273 vaccine

被引：50

作者：

Torrealba-Acosta, Gabriel ^{[1
]}

Martin, Jennifer C. ^{[2
]}

Huttenbach, Yve ^{[3
]}

Garcia, Catherine R. ^{[1
]}

Sohail, Muhammad R. ^{[4
]}

Agarwal, Sandeep Krishna ^{[5
]}

Wasko, Carina ^{[2
]}

Bershad, Eric M. ^{[1
]}

Hirzallah, Mohammad, I ^{[1
]}

机构：

[1] Baylor Coll Med, Neurol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Dermatol, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Dermatopathol, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Med, Sect Infect Dis, Houston, TX 77030 USA

[5] Baylor Coll Med, Dept Med, Sect Immunol Allergy & Rheumatol, Houston, TX 77030 USA

来源：

BMJ CASE REPORTS | 2021年 / 14卷 / 07期

关键词：

COVID-19; dermatology; vaccination; immunisation; neurology; unwanted effects; adverse reactions;

D O I：

10.1136/bcr-2021-243173

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A patient presented with fever, generalised rash, confusion, orofacial movements and myoclonus after receiving the first dose of mRNA-1273 vaccine from Moderna. MRI was unremarkable while cerebrospinal fluid showed leucocytosis with lymphocyte predominance and hyperproteinorrachia. The skin evidenced red, non-scaly, oedematous papules coalescing into plaques with scattered non-follicular pustules. Skin biopsy was consistent with a neutrophilic dermatosis. The patient fulfilled the criteria for Sweet syndrome. A thorough evaluation ruled out alternative infectious, autoimmune or malignant aetiologies, and all manifestations resolved with glucocorticoids. While we cannot prove causality, there was a temporal correlation between the vaccination and the clinical findings.

引用

页数：5

共 19 条

[1] Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults
Anderson, E. J.
Rouphael, N. G.
Widge, A. T.
Jackson, L. A.
Roberts, P. C.
Makhene, M.
Chappell, J. D.
Denison, M. R.
Stevens, L. J.
Pruijssers, A. J.
McDermott, A. B.
Flach, B.
Lin, B. C.
Doria-Rose, N. A.
O'Dell, S.
Schmidt, S. D.
Corbett, K. S.
Swanson, P. A., II
Padilla, M.
Neuzil, K. M.
Bennett, H.
Leav, B.
Makowski, M.
Albert, J.
Cross, K.
Edara, V. V.
Floyd, K.
Suthar, M. S.
Martinez, D. R.
Baric, R.
Buchanan, W.
Luke, C. J.
Phadke, V. K.
Rostad, C. A.
Ledgerwood, J. E.
Graham, B. S.
Beigel, J. H.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (25) : 2427 - 2438
[2] Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine
Baden, Lindsey R.
El Sahly, Hana M.
Essink, Brandon
Kotloff, Karen
Frey, Sharon
Novak, Rick
Diemert, David
Spector, Stephen A.
Rouphael, Nadine
Creech, C. Buddy
McGettigan, John
Khetan, Shishir
Segall, Nathan
Solis, Joel
Brosz, Adam
Fierro, Carlos
Schwartz, Howard
Neuzil, Kathleen
Corey, Larry
Gilbert, Peter
Janes, Holly
Follmann, Dean
Marovich, Mary
Mascola, John
Polakowski, Laura
Ledgerwood, Julie
Graham, Barney S.
Bennett, Hamilton
Pajon, Rolando
Knightly, Conor
Leav, Brett
Deng, Weiping
Zhou, Honghong
Han, Shu
Ivarsson, Melanie
Miller, Jacqueline
Zaks, Tal
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (05) : 403 - 416
[3] Delayed Large Local Reactions to mRNA-1273 Vaccine against SARS-CoV-2
Blumenthal, Kimberly G.
Freeman, Esther E.
Saff, Rebecca R.
Robinson, Lacey B.
Wolfson, Anna R.
Foreman, Ruth K.
Hashimoto, Dean
Banerji, Aleena
Li, Lily
Anvari, Sara
Shenoy, Erica S.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2021, 384 (13) : 1273 - 1277
[4] Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates
Corbett, Kizzmekia S.
Flynn, Barbara
Foulds, Kathryn E.
Francica, Joseph R.
Boyoglu-Barnum, Seyhan
Werner, Anne P.
Flach, Britta
O'Connell, Sarah
Bock, Kevin W.
Minai, Mahnaz
Nagata, Bianca M.
Andersen, Hanne
Martinez, David R.
Noe, Amy T.
Douek, Naomi
Donaldson, Mitzi M.
Nji, Nadesh N.
Alvarado, Gabriela S.
Edwards, Darin K.
Flebbe, Dillon R.
Lamb, Evan
Doria-Rose, Nicole A.
Lin, Bob C.
Louder, Mark K.
O'Dell, Sijy
Schmidt, Stephen D.
Phung, Emily
Chang, Lauren A.
Yap, Christina
Todd, John-Paul M.
Pessaint, Laurent
Van Ry, Alex
Browne, Shanai
Greenhouse, Jack
Putman-Taylor, Tammy
Strasbaugh, Amanda
Campbell, Tracey-Ann
Cook, Anthony
Dodson, Alan
Steingrebe, Katelyn
Shi, Wei
Zhang, Yi
Abiona, Olubukola M.
Wang, Lingshu
Pegu, Amarendra
Yang, Eun Sung
Leung, Kwanyee
Zhou, Tongqing
Teng, I-Ting
Widge, Alicia
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (16) : 1544 - 1555
[5] An interactive web-based dashboard to track COVID-19 in real time
Dong, Ensheng
Du, Hongru
Gardner, Lauren
[J]. LANCET INFECTIOUS DISEASES, 2020, 20 (05) : 533 - 534
[6] An mRNA Vaccine against SARS-CoV-2-Preliminary Report
Jackson, L. A.
Anderson, E. J.
Rouphael, N. G.
Roberts, P. C.
Makhene, M.
Coler, R. N.
McCullough, M. P.
Chappell, J. D.
Denison, M. R.
Stevens, L. J.
Pruijssers, A. J.
McDermott, A.
Flach, B.
Doria-Rose, N. A.
Corbett, K. S.
Morabito, K. M.
O'Dell, S.
Schmidt, S. D.
Swanson, P. A.
Padilla, M.
Mascola, J. R.
Neuzil, K. M.
Bennett, H.
Sun, W.
Peters, E.
Makowski, M.
Albert, J.
Cross, K.
Buchanan, W.
Pikaart-Tautges, R.
Ledgerwood, J. E.
Graham, B. S.
Beigel, J. H.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (20) : 1920 - 1931
[7] Kumar Rashmi, 2020, F1000Res, V9, DOI 10.12688/f1000research.20634.1
[8] Post-vaccinic opsoclonus-myoclonus syndrome: a case report
Lapenna, F
Lochi, L
de Mari, M
Iliceto, G
Lamberti, P
[J]. PARKINSONISM & RELATED DISORDERS, 2000, 6 (04) : 241 - 242
[9] Covid-19: WHO declares pandemic because of "alarming levels" of spread, severity, and inaction
Mahase, Elisabeth
[J]. BMJ-BRITISH MEDICAL JOURNAL, 2020, 368 : m1036
[10] Adverse events following yellow fever immunization: Report and analysis of 67 neurological cases in Brazil
Martins, Reinaldo de Menezes
Braz Pavao, Ana Luiza
Nunes de Oliveira, Patricia Mouta
Gomes dos Santos, Paulo Roberto
Carvalho, Sandra Maria D.
Mohrdieck, Renate
Fernandes, Alexandre Ribeiro
Sato, Helena Keico
de Figueiredo, Patricia Mandali
von Doellinger, Vanessa dos Reis
Fernandes Leal, Maria da Luz
Homma, Akira
Maia, Maria de Lourdes S.
[J]. VACCINE, 2014, 32 (49) : 6676 - 6682

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