Acute encephalitis, myoclonus and Sweet syndrome after mRNA-1273 vaccine

被引：50

作者：

Torrealba-Acosta, Gabriel ^{[1
]}

Martin, Jennifer C. ^{[2
]}

Huttenbach, Yve ^{[3
]}

Garcia, Catherine R. ^{[1
]}

Sohail, Muhammad R. ^{[4
]}

Agarwal, Sandeep Krishna ^{[5
]}

Wasko, Carina ^{[2
]}

Bershad, Eric M. ^{[1
]}

Hirzallah, Mohammad, I ^{[1
]}

机构：

[1] Baylor Coll Med, Neurol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Dermatol, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Dermatopathol, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Med, Sect Infect Dis, Houston, TX 77030 USA

[5] Baylor Coll Med, Dept Med, Sect Immunol Allergy & Rheumatol, Houston, TX 77030 USA

来源：

BMJ CASE REPORTS | 2021年 / 14卷 / 07期

关键词：

COVID-19; dermatology; vaccination; immunisation; neurology; unwanted effects; adverse reactions;

D O I：

10.1136/bcr-2021-243173

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A patient presented with fever, generalised rash, confusion, orofacial movements and myoclonus after receiving the first dose of mRNA-1273 vaccine from Moderna. MRI was unremarkable while cerebrospinal fluid showed leucocytosis with lymphocyte predominance and hyperproteinorrachia. The skin evidenced red, non-scaly, oedematous papules coalescing into plaques with scattered non-follicular pustules. Skin biopsy was consistent with a neutrophilic dermatosis. The patient fulfilled the criteria for Sweet syndrome. A thorough evaluation ruled out alternative infectious, autoimmune or malignant aetiologies, and all manifestations resolved with glucocorticoids. While we cannot prove causality, there was a temporal correlation between the vaccination and the clinical findings.

引用

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