Polygenic scores for smoking and educational attainment have independent influences on academic success and adjustment in adolescence and educational attainment in adulthood

被引：6

作者：

Hicks, Brian M. ^{[1
]}

Clark, D. Angus ^{[1
]}

Deak, Joseph D. ^{[2
,3
]}

Schaefer, Jonathan D. ^{[4
]}

Liu, Mengzhen

Jang, Seonkyeong ^{[5
]}

Durbin, C. Emily ^{[6
]}

Johnson, Wendy ^{[7
]}

Wilson, Sylia ^{[4
]}

Iacono, William G. ^{[5
]}

McGue, Matt ^{[5
]}

Vrieze, Scott I. ^{[5
]}

机构：

[1] Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA

[2] Yale Univ, Dept Psychiat, New Haven, CT USA

[3] Vet Affairs Connecticut Healthcare Ctr, Dept Psychiat, Bridgeport, CT USA

[4] Univ Minnesota, Inst Child Dev, Minneapolis, MN USA

[5] Univ Minnesota, Dept Psychol, Minneapolis, MN USA

[6] Michigan State Univ, Dept Psychol, E Lansing, MI 48824 USA

[7] Univ Edinburgh, Dept Psychol, Edinburgh, Midlothian, Scotland

来源：

PLOS ONE | 2021年 / 16卷 / 08期

关键词：

BEHAVIORAL DISINHIBITION; HEALTH; ASSOCIATION; PANEL; TWIN;

D O I：

10.1371/journal.pone.0255348

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Educational success is associated with greater quality of life and depends, in part, on heritable cognitive and non-cognitive traits. We used polygenic scores (PGS) for smoking and educational attainment to examine different genetic influences on facets of academic adjustment in adolescence and educational attainment in adulthood. PGSs were calculated for participants of the Minnesota Twin Family Study (N = 3225) and included as predictors of grades, academic motivation, and discipline problems at ages 11, 14, and 17 years-old, cigarettes per day from ages 14 to 24 years old, and educational attainment in adulthood (mean age 29.4 years). Smoking and educational attainment PGSs had significant incremental associations with each academic variable and cigarettes per day. About half of the adjusted effects of the smoking and education PGSs on educational attainment in adulthood were mediated by the academic variables in adolescence. Cigarettes per day from ages 14 to 24 years old did not account for the effect of the smoking PGS on educational attainment, suggesting the smoking PGS indexes genetic influences related to general behavioral disinhibition. In sum, distinct genetic influences measured by the smoking and educational attainment PGSs contribute to academic adjustment in adolescence and educational attainment in adulthood.

引用

页数：15