An influence of ABO blood group on the rate of proteolysis of von Willebrand factor by ADAMTS13

被引：144

作者：

Bowen, DJ ^{[1
]}

机构：

[1] Univ Wales Coll Cardiff, Coll Med, Dept Haematol, Cardiff CF14 4XN, S Glam, Wales

来源：

JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2003年 / 1卷 / 01期

关键词：

ABO blood-group system; blood proteins; endopeptidases; von Willebrand disease; von Willebrand factor;

D O I：

10.1046/j.1538-7836.2003.00007.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The susceptibility of von Willebrand factor (VWF) of blood group O, A. B and AB to proteolysis by the ADAMTS13 metalloprotease was investigated. Multimeric analysis indicated that the rate of VWF proteolysis differed between blood groups and was greater for group O VWF than for non-O VWF in the rank order O greater than or equal to B > A greater than or equal to AB. Measurement of the collagen binding activity of VWF of each blood group following proteolysis for a fixed time interval corroborated the results obtained on multimer analysis: the loss of collagen binding activity was greater for VWF of group O compared with non-O VWF, in the rank order O greater than or equal to B > A greater than or equal to AB. Ristocetin was found to increase the rate of VWF proteolysis approximately two-fold the differential between blood groups was retained in the presence of ristocetin.

引用

页码：33 / 40

页数：8

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