Type 2 Diabetes, Skin Autofluorescence, and Brain Atrophy

被引：58

作者：

Moran, Chris ^{[1
,2
]}

Muench, Gerald ^{[3
,4
]}

Forbes, Josephine M. ^{[5
,6
]}

Beare, Richard ^{[1
,2
,7
]}

Blizzard, Leigh ^{[8
]}

Venn, Alison J. ^{[8
]}

Phan, Thanh G. ^{[1
,2
]}

Chen, Jian ^{[1
,2
,7
]}

Srikanth, Velandai ^{[1
,2
,8
]}

机构：

[1] Monash Univ, Southern Clin Sch, Dept Med, Stroke & Ageing Res Grp, Melbourne, Vic 3004, Australia

[2] Monash Hlth, Monash Med Ctr, Neurosci, Melbourne, Australia

[3] Univ Western Sydney, Sch Med, Dept Pharmacol, Sydney, NSW, Australia

[4] Univ Western Sydney, Mol Med Res Grp, Sydney, NSW, Australia

[5] Mater Univ Queensland, Translat Res Inst, Brisbane, Qld, Australia

[6] Univ Queensland, Mater Clin Sch, Brisbane, Qld 4072, Australia

[7] Murdoch Childrens Res Inst, Melbourne, Australia

[8] Menzies Res Inst Tasmania, Hobart, Tas, Australia

来源：

DIABETES | 2015年 / 64卷 / 01期

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

GLYCATION END-PRODUCTS; TUBULAR CELL INJURY; ALZHEIMER-DISEASE; ACCUMULATION; IRBESARTAN; RECEPTOR; STRESS; LEVEL;

D O I：

10.2337/db14-0506

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Type 2 diabetes mellitus (T2DM) is associated with brain atrophy, but the mechanisms underlying this link are unknown. Advanced glycation end products (AGEs) accumulate in T2DM, resulting in inflammation, oxidative stress, and protein cross-linking, which are known contributors to neurodegeneration. We aimed to study whether tissue AGE accumulation is associated with T2DM-related brain atrophy. We performed brain magnetic resonance imaging, cognitive tests, and noninvasive skin autofluorescence (SAF; a measure of tissue AGE levels) on people aged > 55 years with and without T2DM. Multivariable linear regression was used to study the relationships among T2DM, SAF, and gray matter volume (GMV). There were 486 people included in the study. T2DM was associated with greater SAF. Greater SAF, T2DM, and cognitive impairment were each associated with lower GMV independently of age, sex, and total intracranial volume. SAF partially mediated the association between T2DM and GMV. Longitudinal studies may help confirm whether tissue AGE accumulation is associated with brain atrophy in T2DM.

引用

页码：279 / 283

页数：5

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