Capsaicin-sensitive sensory neurons contribute to the maintenance of trabecular bone integrity

被引：125

作者：

Offley, SC

Guo, TZ

Wei, TP

Clark, JD

Vogel, H

Lindsey, DP

Jacobs, CR

Yao, W

Lane, NE

Kingery, WS

机构：

[1] Vet Affairs Palo Alto Hlth Care Syst, Phys Med & Rehabil Serv 117, Palo Alto, CA 94304 USA

[2] Vet Affairs Palo Alto Hlth Care Syst, Anesthesiol Serv, Palo Alto, CA 94304 USA

[3] Stanford Univ, Sch Med, Dept Anesthesia, Stanford, CA 94305 USA

[4] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA

[5] Vet Affairs Palo Alto Hlth Care Syst, Rehabil Res & Dev Ctr, Palo Alto, CA 94304 USA

[6] Stanford Univ, Sch Engn, Dept Engn Mech, Stanford, CA 94305 USA

[7] Stanford Univ, Sch Med, Dept Orthoped Surg, Stanford, CA 94305 USA

[8] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 02期

关键词：

substance P; calcitonin gene-related peptide; capsaicin; osteoporosis; bone; BMD;

D O I：

10.1359/JBMR.041108

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This investigation used capsaicin to selectively lesion unmyelinated sensory neurons in rats. Neuronal lesioning induced a loss of trabecular integrity, reduced bone mass and strength, and depleted neuropeptides in nerve and bone. These data suggest that capsaicin-sensitive sensory nerves contribute to trabecular bone integrity.

引用

页码：257 / 267

页数：11

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