Capsaicin-sensitive sensory neurons contribute to the maintenance of trabecular bone integrity

被引：126
作者：
Offley, SC
Guo, TZ
Wei, TP
Clark, JD
Vogel, H
Lindsey, DP
Jacobs, CR
Yao, W
Lane, NE
Kingery, WS
机构：
[1] Vet Affairs Palo Alto Hlth Care Syst, Phys Med & Rehabil Serv 117, Palo Alto, CA 94304 USA
[2] Vet Affairs Palo Alto Hlth Care Syst, Anesthesiol Serv, Palo Alto, CA 94304 USA
[3] Stanford Univ, Sch Med, Dept Anesthesia, Stanford, CA 94305 USA
[4] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
[5] Vet Affairs Palo Alto Hlth Care Syst, Rehabil Res & Dev Ctr, Palo Alto, CA 94304 USA
[6] Stanford Univ, Sch Engn, Dept Engn Mech, Stanford, CA 94305 USA
[7] Stanford Univ, Sch Med, Dept Orthoped Surg, Stanford, CA 94305 USA
[8] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 02期
关键词：
substance P; calcitonin gene-related peptide; capsaicin; osteoporosis; bone; BMD;
D O I：
10.1359/JBMR.041108
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This investigation used capsaicin to selectively lesion unmyelinated sensory neurons in rats. Neuronal lesioning induced a loss of trabecular integrity, reduced bone mass and strength, and depleted neuropeptides in nerve and bone. These data suggest that capsaicin-sensitive sensory nerves contribute to trabecular bone integrity.
引用
收藏
页码：257 / 267
页数：11
相关论文
共 76 条
  • [1] Effects of capsaicin-induced sensory denervation on osteoclastic resorption in adult rats
    Adam, C
    Llorens, A
    Baroukh, B
    Cherruau, M
    Saffar, JL
    [J]. EXPERIMENTAL PHYSIOLOGY, 2000, 85 (01) : 61 - 66
  • [2] Adamus MA, 2001, J CELL BIOCHEM, V81, P499, DOI 10.1002/1097-4644(20010601)81:3<499::AID-JCB1063>3.0.CO
  • [3] 2-Y
  • [4] Effects of CGRP on human osteoclast-like cell formation: a possible connection with the bone loss in neurological disorders?
    Akopian, A
    Demulder, A
    Ouriaghli, F
    Corazza, F
    Fondu, P
    Bergmann, P
    [J]. PEPTIDES, 2000, 21 (04) : 559 - 564
  • [5] Alhashimi N, 2004, ANGLE ORTHOD, V74, P100
  • [6] Orthodontic tooth movement and de novo synthesis of proinflammatory cytokines
    Alhashimi, N
    Frithiof, L
    Brudvik, P
    Bakhiet, M
    [J]. AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS, 2001, 119 (03) : 307 - 312
  • [7] AXELROD FB, 1995, AUT NER SYS, V5, P217
  • [8] Bergman E, 1996, J COMP NEUROL, V375, P303
  • [9] THE OSTEOGENIC STIMULATING EFFECT OF NEUROACTIVE CALCITONIN GENE-RELATED PEPTIDE
    BERNARD, GW
    SHIH, C
    [J]. PEPTIDES, 1990, 11 (04) : 625 - 632
  • [10] BJURHOLM A, 1991, INT ORTHOP, V15, P325
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