Identification of a non peptidic RANTES antagonist

被引：11

作者：

Bright, C ^{[1
]}

Brown, TJ ^{[1
]}

Cox, P ^{[1
]}

Halley, F ^{[1
]}

Lockey, P ^{[1
]}

McLay, IM ^{[1
]}

Moore, U ^{[1
]}

Porter, B ^{[1
]}

Williams, RJ ^{[1
]}

机构：

[1] Rhone Poulenc Rorer, Dagenham Res Ctr, Dagenham RM10 7XS, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(98)00094-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of phenothiazines demonstrating inhibition of RANTES binding to THP-1 cell membranes has been identified. The lead compound RP23618 (IC50=3 mu M) was found to inhibit specific binding of I-125-RANTES, but not I-125-MCP-1 to THP-1 cell membranes and furthermore to antagonise RANTES, but not MCP-1-induced chemotaxis of THP-1 cells. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：771 / 774

页数：4

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