Enhancing Mood, Cognition, and Quality of Life in Pediatric Multiple Sclerosis

被引：7

作者：

Fernandez-Carbonell, Cristina ^{[1
]}

Charvet, Leigh E. ^{[2
]}

Krupp, Lauren B. ^{[2
]}

机构：

[1] Northwell Hlth, Cohens Children Med Ctr, New York, NY 10065 USA

[2] NYU, Langone Pediat Multiple Sclerosis Ctr, New York, NY USA

来源：

PEDIATRIC DRUGS | 2021年 / 23卷 / 04期

关键词：

VITAMIN-D STATUS; HIGH-DOSE BIOTIN; DOUBLE-BLIND; PHYSICAL-ACTIVITY; SLEEP DISORDERS; RELAPSE RATE; EXERCISE THERAPY; CONTROLLED-TRIAL; D DEFICIENCY; RISK-FACTORS;

D O I：

10.1007/s40272-021-00451-5

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Pediatric-onset multiple sclerosis (POMS), representing approximately 5% of all MS cases, affects the central nervous system during its ongoing development. POMS is most commonly diagnosed during adolescence but can occur in younger children as well. For pediatric patients with MS, it is critical to manage the full impact of the disease and monitor for any effects on school and social functioning. Disease management includes not only disease-modifying therapies but also strategies to optimize wellbeing. We review the interventions with the highest evidence of ability to improve the disease course and quality of life in POMS. High levels of vitamin D and a diet low in saturated fat are associated with lower relapse rates. Exercise ameliorates fatigue and sleep. Behavioral strategies for sleep hygiene and mood regulation can also improve fatigue and perceived health. POMS management should be addressed holistically, including assessing overall symptom burden as well as the psychological and functional impact of the disease.

引用

页码：317 / 329

页数：13

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