The objective of this study was to establish the association of the Social Determinants of Health (DSS) with the degree of disability in a population over 18 years of age in the city of Barranquilla. A descriptive study was carried out, with 216 people with disabilities. As a dependent variable, the degree of disability was measured with the WHODAS 2.0 and the social determinants of health were evaluated as independent variables. 56.9% were women, the average age was 53.68 years, according to the degree of disability the highest percentage was found in the extreme degree the activities of daily living-paid work and in the moderate degree the domains of participation in society. As the age increases, the hours of work, the time of work and the years without rehabilitation are affected the domains of understanding and communication, mobility, self-care, relationships with other people, activities of daily life-unpaid work, activities of daily living-paid work, participation in society and with the final disability degree and that this association is statistically significant p <0.05. It is concluded that there is an association between the social determinants of health and the degree of disability in the population studied.