WISP1 Polymorphisms Contribute to Platinum-Based Chemotherapy Toxicity in Lung Cancer Patients

被引：27
作者：
Chen, Juan [1 ,2 ]
Yin, Jiye [1 ,2 ]
Li, Xiangping [1 ,2 ]
Wang, Ying [3 ]
Zheng, Yi [1 ,2 ]
Qian, Chenyue [1 ,2 ]
Xiao, Ling [1 ,2 ]
Zou, Ting [1 ,2 ]
Wang, Zhan [4 ]
Liu, Junyan [5 ]
Zhang, Wei [1 ,2 ]
Zhou, Honghao [1 ,2 ]
Liu, Zhaoqian [1 ,2 ]
机构：
[1] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China
[2] Cent S Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410008, Hunan, Peoples R China
[3] Cent S Univ, Affiliated Canc Hosp, XiangYa Sch Med, Changsha 410008, Hunan, Peoples R China
[4] Cent S Univ, Dept Oncol, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China
[5] Cent S Univ, Xiangya Sch Med, Changsha 410008, Hunan, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 11期
基金：
中国国家自然科学基金;
关键词：
WISP1; lung cancer; genetic polymorphism; chemotherapy toxicity; INDUCED CARDIOMYOCYTE DEATH; DNA-REPAIR; PROTEIN-1; CELLS; ASSOCIATION; EXPRESSION; CARCINOMA; SURVIVAL; FAMILY; PROLIFERATION;
D O I：
10.3390/ijms151121011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Platinum-based chemotherapy toxicity is always one of the serious problems from which lung cancer patients suffer. The genetic polymorphism of WISP1 was revealed to be associated with susceptibility and platinum-based chemotherapy response in our previous studies. In this study, we aimed to investigate the relationship of WISP1 genetic polymorphisms with platinum-based chemotherapy toxicity in lung cancer patients. A total of 412 lung cancer patients were enrolled in this study, and 28 polymorphisms of the WISP1 gene were genotyped by SequenomMassARRAY. We found that WISP1 polymorphisms (rs2929965, rs2929969, rs2929970, rs2929973 and rs754958) were related to the overall chemotherapy toxicity of lung cancer in subgroup analyses. Rs16904853, rs2929970, rs2977549 and rs2977551 (p = 0.021, 0.028, 0.024, 0.048, respectively) polymorphisms were significantly associated with hematologic toxicity. Rs2929946, rs2929970, rs2977519, rs2977536, rs3739262 and rs754958 (p = 0.031, 0.046, 0.029, 0.016, 0.042, 0.035, respectively) polymorphisms were significantly associated with the gastrointestinal toxicity of lung cancer. Genotypes of WISP1 may be novel and useful biomarkers for predicting platinum-based chemotherapy toxicity in lung cancer patients.
引用
收藏
页码：21011 / 21027
页数：17
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