Facile synthesis of caerulomycin E by the formation of 2,2′-bipyridine core via a 2-pyridyl substituted 4H-pyran-4-one. Formal synthesis of caerulomycin A

被引：16

作者：

Bobrov, Denis N. ^{[1
]}

Tyvorskii, Vladimir I. ^{[2
]}

机构：

[1] Oasmia Pharmaceut AB, SE-75228 Uppsala, Sweden

[2] Belarusian State Univ, Dept Organ Chem, Minsk 220030, BELARUS

来源：

TETRAHEDRON | 2010年 / 66卷 / 29期

关键词：

Caerulomycins; 4H-Pyran-4-ones; 2,2 '-Bipyridines; Claisen condensation; STREPTOMYCES-CAERULEUS; INHIBITORS; DERIVATIVES;

D O I：

10.1016/j.tet.2010.05.024

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new approach to caerulomycins A and E via a 6-methyl-2-(2-pyridyl)-4H-pyran-4-one is described. The pyranone precursor is prepared by Claisen condensation of acetylacetone enol ether with ethyl picolinate. (C) 2010 Elsevier Ltd. All rights reserved.

引用

收藏

页码：5432 / 5434

页数：3

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