Base pairs and pseudo pairs observed in RNA-ligand complexes

被引:17
|
作者
Kondo, Jiro [1 ]
Westhof, Eric [1 ]
机构
[1] Univ Strasbourg, Architecture & React I ARN, Inst Biol Mol & Cellulaire, CNRS, F-67084 Strasbourg, France
基金
美国国家卫生研究院;
关键词
RNA; base pairs; antibiotics; riboswitch; aptamer; X-ray; recognition; PEPTIDYL-TRANSFERASE CENTER; 30S RIBOSOMAL-SUBUNIT; GROUP-I INTRON; DIMERIZATION INITIATION SITE; ANGSTROM CRYSTAL-STRUCTURE; RIBOSWITCH APTAMER DOMAIN; HIV-1 TAR RNA; STRUCTURAL BASIS; MOLECULAR RECOGNITION; PURINE RIBOSWITCH;
D O I
10.1002/jmr.978
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Previously, a geometric nomenclature was proposed in which RNA base pairs were classified by their interaction edges (Watson-Crick, Hoogsteen or sugar-edge) and the glycosidic bond orientations relative to the hydrogen bonds formed (cis or trans). Here, base pairs and pseudo pairs observed in RNA-ligand complexes are classified in a similar manner. Twenty-one basic geometric families are geometrically possible (18 for base pairs formed between a nucleic acid base and a ligand containing heterocycle and 3 families for pseudo pairs). Of those, 16 of them have been observed in X-ray and/or NMR structures. Copyright (C) 2009 John Wiley & Sons, Ltd.
引用
收藏
页码:241 / 252
页数:12
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