Base pairs and pseudo pairs observed in RNA-ligand complexes

被引：17

作者：

Kondo, Jiro ^{[1
]}

Westhof, Eric ^{[1
]}

机构：

[1] Univ Strasbourg, Architecture & React I ARN, Inst Biol Mol & Cellulaire, CNRS, F-67084 Strasbourg, France

来源：

JOURNAL OF MOLECULAR RECOGNITION | 2010年 / 23卷 / 02期

基金：

美国国家卫生研究院;

关键词：

RNA; base pairs; antibiotics; riboswitch; aptamer; X-ray; recognition; PEPTIDYL-TRANSFERASE CENTER; 30S RIBOSOMAL-SUBUNIT; GROUP-I INTRON; DIMERIZATION INITIATION SITE; ANGSTROM CRYSTAL-STRUCTURE; RIBOSWITCH APTAMER DOMAIN; HIV-1 TAR RNA; STRUCTURAL BASIS; MOLECULAR RECOGNITION; PURINE RIBOSWITCH;

D O I：

10.1002/jmr.978

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Previously, a geometric nomenclature was proposed in which RNA base pairs were classified by their interaction edges (Watson-Crick, Hoogsteen or sugar-edge) and the glycosidic bond orientations relative to the hydrogen bonds formed (cis or trans). Here, base pairs and pseudo pairs observed in RNA-ligand complexes are classified in a similar manner. Twenty-one basic geometric families are geometrically possible (18 for base pairs formed between a nucleic acid base and a ligand containing heterocycle and 3 families for pseudo pairs). Of those, 16 of them have been observed in X-ray and/or NMR structures. Copyright (C) 2009 John Wiley & Sons, Ltd.

引用

页码：241 / 252

页数：12

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