Hypoxia-induced up-regulation of Aquaporin-1 in Rat Schwann cells via the MAPK pathway

被引：0

作者：

Meng, Wei ^{[1
]}

Hu, Hao ^{[1
]}

Jie, Xiang ^{[1
]}

Gao, Yak ^{[1
]}

Zhu, Lie ^{[1
]}

Zhang, Ying ^{[1
]}

Zhao, Yaozh ^{[1
]}

Wang, Hui ^{[1
]}

Jiang, Hua ^{[1
]}

机构：

[1] Second Mil Med Univ, Changzheng Hosp, Dept Plast & Reconstruct Surg, 415 Fengyang Rd, Shanghai 200003, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2017年 / 10卷 / 06期

基金：

中国国家自然科学基金;

关键词：

Aquaporin-1; Schwann cells; hypoxia; MAPK; WATER CHANNEL; PROTEIN-KINASE; EXPRESSION; ACTIVATION; BRAIN; MICE; ASTROCYTES; ISCHEMIA; GROWTH; MODEL;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background: Aquaporin-1 (AQP1) is a glycoprotein that mediates osmotic water transport. Its expression has been found to be correlated with the swelling of Schwann cells. Hypoxia has been reported to play an important role in inducing the expression of AQP1 during Schwann cell swelling. However, the mechanism that regulates AQP1 expression in Schwann cells remains obscure. Methods: The expression and regulation of AQP1 in Rat Schwann cells was investigated using a tris-gas incubator to build a hypoxia model. Results: The expression of AQP1 was up-regulated upon the induction of hypoxia in cells. Hypoxia also induced the phosphorylation of ERK/p38/JNK MAPK. Specific inhibitors of ERK and p38 MAPK blocked these effects of hypoxia on the expression of AQP1. Conclusion: These findings suggested that AQP1 could be up-regulated in a time-dependent manner by hypoxia at the cellular level and that the regulation of AQP1 in Schwann cells was dependent on ERK and p38 MAPK.

引用

页码：9271 / 9276

页数：6

共 23 条

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