Infant Growth During the First Year of Life and Subsequent Hospitalization to 8 Years of Age

被引:3
作者
Hui, L. L. [1 ,2 ]
Schooling, C. Mary [1 ,2 ]
Wong, M. Y. [3 ]
Ho, L. M. [1 ,2 ]
Lam, T. H. [1 ,2 ]
Leung, Gabriel M. [1 ,2 ]
机构
[1] Univ Hong Kong, Dept Community Med, Li Ka Shing Fac Med, Hong Kong, Hong Kong, Peoples R China
[2] Univ Hong Kong, Sch Publ Hlth, Li Ka Shing Fac Med, Hong Kong, Hong Kong, Peoples R China
[3] Hong Kong Univ Sci & Technol, Dept Math, Hong Kong, Hong Kong, Peoples R China
关键词
ENVIRONMENTAL TOBACCO-SMOKE; FOR-GESTATIONAL-AGE; BIRTH-WEIGHT; INFECTIOUS-DISEASE; CHILDHOOD; GAIN; HEALTH; RISK;
D O I
暂无
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background: There is accumulating evidence that rapid infant growth is associated with subsequent metabolic risk, but less investigation of potential benefits. We tested the life history trade-off hypothesis that rapid infant growth is associated with lower risk of serious childhood morbidity (in particular, infection) proxied by hospital admission. Methods: We studied term births (n = 7833, 94% follow-up) from a Chinese birth cohort, "Children of 1997," comprising 88% of births in Hong Kong in April and May 1997. We used multivariable negative binomial regression to examine the association of growth trajectory (5 categories) from birth to 12 months with subsequent hospital admissions until the child's 8th birthday. Potential confounders included sex, gestational age, parental education, type of birth hospital, infant feeding, and the presence of congenital disease. Results: Infants with the slowest growth trajectory (smallest birth weight and slowest weight gain) were more likely to be hospitalized between 1 and 8 years of age-particularly for noninfectious illnesses. Infants in the 4 faster growth trajectories differed little in their risk of hospitalization. Adjusted incident rate ratios of hospitalization for infectious diseases were 0.93 (95% confidence interval = 0.81-1.06), 0.97 (0.85-1.12), 0.91 (0.78-1.06), and 0.92 (0.79-1.08) for the 4 faster growth trajectories compared with the slowest. Results were similar when growth was assessed as change in weight-for-age z-score. Conclusion: Fast infant growth does not protect against serious infectious morbidity, but low birth weight infants born with slow growth are more vulnerable to serious morbidity, either as a consequence of poor growth or as a parallel marker of underlying health state. Whether maximum growth rates are ideal should be considered, as should the effects of infant over-nutrition.
引用
收藏
页码:332 / 339
页数:8
相关论文
共 29 条
[1]  
[Anonymous], 2009, Modern epidemiology
[2]   Early growth and adult respiratory function in men and women followed from the fetal period to adulthood [J].
Canoy, Dexter ;
Pekkanen, Juha ;
Elliott, Paul ;
Pouta, Anneli ;
Laitinen, Jaana ;
Hartikainen, Anna-Liisa ;
Zitting, Paavo ;
Patel, Swatee ;
Little, Mark P. ;
Jarvelin, Marjo-Riitta .
THORAX, 2007, 62 (05) :396-402
[3]   GROWTH-PATTERNS OF LOW-BIRTH-WEIGHT PRETERM INFANTS - A LONGITUDINAL ANALYSIS OF A LARGE, VARIED SAMPLE [J].
CASEY, PH ;
KRAEMER, HC ;
BERNBAUM, J ;
TYSON, JE ;
SELLS, JC ;
YOGMAN, MW ;
BAUER, CR .
JOURNAL OF PEDIATRICS, 1990, 117 (02) :298-307
[4]  
*CENS STAT DEP, 2003, 12 GOV HONG KONG SAR
[5]   WHO Child Growth Standards based on length/height, weight and age [J].
de Onis, Mercedes ;
Martorell, Reynaldo ;
Garza, Cutberto ;
Lartey, Anna .
ACTA PAEDIATRICA, 2006, 95 :76-85
[6]   Association of weight gain in infancy and early childhood with metabolic risk in young adults [J].
Ekelund, Ulf ;
Ong, Ken K. ;
Linne, Yvonne ;
Neovius, Martin ;
Brage, Soren ;
Dunger, David B. ;
Wareham, Nicholas J. ;
Rossner, Stephan .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2007, 92 (01) :98-103
[7]  
GOODMAN LA, 1974, BIOMETRIKA, V61, P215, DOI 10.1093/biomet/61.2.215
[8]   Birth weight, infant growth, and childhood body mass index [J].
Hui, L. L. ;
Schooling, C. Mary ;
Leung, Shirley Sze Lee ;
Mak, Kwok Hang ;
Ho, Lai Ming ;
Lam, Tai Hing ;
Leung, Gabriel M. .
ARCHIVES OF PEDIATRICS & ADOLESCENT MEDICINE, 2008, 162 (03) :212-218
[9]   The impact of birth weight on infectious disease hospitalization in childhood [J].
Hviid, Anders ;
Melbye, Mads .
AMERICAN JOURNAL OF EPIDEMIOLOGY, 2007, 165 (07) :756-761
[10]   Having it all: historical energy intakes do not generate the anticipated trade-offs in fecundity [J].
Johnston, S. L. ;
Grune, T. ;
Bell, L. M. ;
Murray, S. J. ;
Souter, D. M. ;
Erwin, S. S. ;
Yearsley, J. M. ;
Gordon, I. J. ;
Illius, A. W. ;
Kyriazakis, I. ;
Speakman, J. R. .
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2006, 273 (1592) :1369-1374