Prostate-specific membrane antigen for the surgical oncologist: interpreting expression beyond the prostate

被引：5
|
作者：
Farag, Matthew [1 ,2 ]
Bolton, Damien [1 ,2 ]
Lawrentschuk, Nathan [1 ,2 ]
机构：
[1] Univ Melbourne, Dept Surg, Melbourne, Vic 3084, Australia
[2] Austin Hlth, Dept Urol, Melbourne, Vic, Australia
来源：
ANZ JOURNAL OF SURGERY | 2020年 / 90卷 / 05期
关键词：
general surgery; PSMA; surgical oncology; urology; PSMA; TARGET; NEOVASCULATURE; TISSUES; PROTEIN;
D O I：
10.1111/ans.15479
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
The use of prostate-specific membrane antigen (PSMA) radiotracer in positron emission tomography (PET) has been successfully incorporated into the clinical management of prostate cancer. However, PSMA tracer uptake is not limited to prostate cancer tissue. We reviewed studies exploring PSMA expression beyond the prostate gland using techniques of Ga-68-PSMA PET imaging and immunohistochemistry. PSMA expression has been associated with a variety of solid tumours, and the vasculature associated with neoplastic disease, suggesting that this trans-membrane glycoprotein may be involved in the neovascularisation process in malignancy. These studies demonstrate the need for more research into the potential utility for Ga-68-PSMA PET imaging in patients with non-prostatic cancers.
引用
收藏
页码：715 / 718
页数：4
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