Inflammatory factors, genetic variants, and predisposition for preterm birth

被引：27

作者：

Couceiro, Joana ^{[1
,2
,3
]}

Matos, Irina ^{[1
]}

Mendes, Jose Joao ^{[1
]}

Baptista, Pedro V. ^{[2
]}

Fernandes, Alexandra R. ^{[2
]}

Quintas, Alexandre ^{[1
,3
]}

机构：

[1] Ctr Invest Interdisciplinar Egas Moniz, Campus Univ Quinta Granja, P-2829511 Caparica, Portugal

[2] Univ NOVA Lisboa, Fac Ciencias & Tecnol, Dept Ciencias Vida, UCIBIO, Campus Caparica, Caparica, Portugal

[3] Lab Ciencias Forenses & Psicol Egas Moniz, Campus Univ Quinta Granja, Caparica, Portugal

来源：

CLINICAL GENETICS | 2021年 / 100卷 / 04期

关键词：

autoimmune diseases; genetic variants; inflammation; inflammatory diseases; preterm birth; TUMOR-NECROSIS-FACTOR; SINGLE-NUCLEOTIDE POLYMORPHISMS; INTERLEUKIN-1 RECEPTOR ANTAGONIST; BOWEL-DISEASE; PREMATURE RUPTURE; FACTOR-ALPHA; FETAL MEMBRANES; TNF-ALPHA; RACIAL DISPARITIES; CROHNS-DISEASE;

D O I：

10.1111/cge.14001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Preterm birth is a major clinical and public health challenge, with a prevalence of 11% worldwide. It is the leading cause of death in children younger than 5 years old and represents 70% of neonatal deaths and 75% of neonatal morbidity. Despite the clinical and public health significance, this condition's etiology is still unclear, and most of the cases are spontaneous. There are several known preterm birth risk factors, including inflammatory diseases and the genetic background, although the underlying molecular mechanisms are far from understood. The present review highlights the research advances on the association between inflammatory-related genes and the increased risk for preterm delivery. The most associated genetic variants are the TNF alpha rs1800629, the IL1 alpha rs17561, and the IL1RN rs2234663. Moreover, many of the genes discussed in this review are also implicated in pathologies involving inflammatory or autoimmune systems, such as periodontal disease, bowel inflammatory disease, and autoimmune rheumatic diseases. This review presents evidence suggesting a common genetic background to preterm birth, autoimmune and inflammatory diseases susceptibility.

引用

页码：357 / 367

页数：11

共 152 条

[1] Tumor necrosis factor-α promoter variant 2 (TNF2) is associated with pre-term delivery, infant mortality, and malaria morbidity in western Kenya:: Asenibo Bay Cohort project IX [J].