Bioactive Octahydroxylated C21 Steroids from the Root Bark of Lycium chinense

被引：16

作者：

An, Ya-Wen ^{[1
,2
]}

Zhan, Zhi-Lai ^{[1
,2
,3
]}

Xie, Jing ^{[1
,2
]}

Yang, Ya-Nan ^{[1
,2
]}

Jiang, Jian-Shuang ^{[1
,2
]}

Feng, Zi-Ming ^{[1
,2
]}

Ye, Fei ^{[1
,2
]}

Zhang, Pei-Cheng ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Substance & Funct Nat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

[3] China Acad Chinese Med Sci, Natl Resource Ctr Chinese Mat Med, State Key Lab Breeding Base Daodi Herbs, Beijing 100700, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2016年 / 79卷 / 04期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

TI-KU-PI; FATTY-ACIDS; KUKOAMINE-B; BETA-CELLS; GLYCOSIDES; AUTOPHAGY; LIGNANAMIDES; CONSTITUENTS; AMIDES; PEPTIDES;

D O I：

10.1021/acs.jnatprod.5b01087

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Lyciumsterols A-K (1-11), 11 new octahydroxylated C-21 steroids, were isolated from the root bark of Lycium chinense, along with 15 known compounds. Characterization of these C-21 steroids showed the presence of eight hydroxy groups on the C-21 steroid skeleton with a (2E,4E)-5-phenyl-2,4-pentadienoate group at C-12 or C-20 and various 2,6-deoxy sugar residues at C-3. The structures of these compounds were elucidated using spectroscopic data interpretation. Compounds 2, 3, and 7 exhibited dose-dependent protective effects on pancreatic islet cells and may help to improve cell viability. In addition, it was found that compounds 7, 8, 9, and 11 exhibited autophagy activation.

引用

页码：1024 / 1034

页数：11

共 46 条

[21] New acetylcholinesterase-inhibitory pregnane glycosides of Cynanchum atratum roots [J].

Lee, KY ;

Sung, SH ;

Kim, YC .

HELVETICA CHIMICA ACTA, 2003, 86 (02) :474-483

[22] Identification and Evaluation of Antiepileptic Activity of C21 Steroidal Glycosides from the Roots of Cynanchum wilfordii [J].

Li, Jin-Long ;

Gao, Zhao-Bing ;

Zhao, Wei-Min .

JOURNAL OF NATURAL PRODUCTS, 2016, 79 (01) :89-97

[23]

Lin CC, 1996, PHYTOTHER RES, V10, P651, DOI 10.1002/(SICI)1099-1573(199612)10:8<651::AID-PTR651>3.0.CO

[24]

2-L

[25] Dual targets guided screening and isolation of Kukoamine B as a novel natural anti-sepsis agent from traditional Chinese herb Cortex lycii [J].

Liu, Xin ;

Zheng, Xinchuan ;

Long, Yupeng ;

Cao, Hongwei ;

Wang, Ning ;

Lu, Yongling ;

Zhao, Kecen ;

Zhou, Hong ;

Zheng, Jiang .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2011, 11 (01) :110-120

[26]

Maldoni B. E., 1988, REV LATINOAM QUIM, V19, P15

[27] Inhibition of Autophagic Turnover in β-Cells by Fatty Acids and Glucose Leads to Apoptotic Cell Death [J].

Mir, Shakeel U. R. ;

George, Nicholas M. ;

Zahoor, Lubna ;

Harms, Robert ;

Guinn, Zachary ;

Sarvetnick, Nora E. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (10) :6071-6085

[28] Antimutagenic activity of flavonoids from Chrysanthemum morifolium [J].

Miyazawa, M ;

Hisama, M .

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2003, 67 (10) :2091-2099

[29] Methods in Mammalian Autophagy Research [J].

Mizushima, Noboru ;

Yoshimori, Tamotsu ;

Levine, Beth .

CELL, 2010, 140 (03) :313-326

[30]

NOGUCHI M, 1984, CHEM PHARM BULL, V32, P3584

← 1 2 3 4 5 →