Cytotoxicity-Related Bioeffects Induced by Nanoparticles: The Role of Surface Chemistry

被引：95

作者：

Sun, Hainan ^{[1
,2
]}

Jiang, Cuijuan ^{[3
]}

Wu, Ling ^{[1
]}

Bai, Xue ^{[1
]}

Zhai, Shumei ^{[1
]}

机构：

[1] Shandong Univ, Key Lab Colloid & Interface Chem, Minist Educ, Sch Chem & Chem Engn, Jinan, Shandong, Peoples R China

[2] Shandong Vocat Coll Light Ind, Zibo, Peoples R China

[3] Shandong Univ, Sch Environm Sci & Engn, Qingdao, Shandong, Peoples R China

来源：

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2019年 / 7卷

基金：

中国国家自然科学基金;

关键词：

nanoparticles; surface chemistry; charge; hydrophobicity; PEG; cytotoxicity; MULTIWALLED CARBON NANOTUBES; AUTOPHAGIC CELL-DEATH; PROTEIN CORONA; GOLD NANOPARTICLES; OXIDATIVE STRESS; SILICA NANOPARTICLES; IN-VIVO; QUANTUM DOTS; OXIDE NANOPARTICLES; GENE-EXPRESSION;

D O I：

10.3389/fbioe.2019.00414

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nanoparticles (NPs) are widely used in a variety of fields, including those related to consumer products, architecture, energy, and biomedicine. Once they enter the human body, NPs contact proteins in the blood and interact with cells in organs, which may induce cytotoxicity. Among the various factors of NP surface chemistry, surface charges, hydrophobicity levels and combinatorial decorations are found to play key roles inregulating typical cytotoxicity-related bioeffects, including protein binding, cellular uptake, oxidative stress, autophagy, inflammation, and apoptosis. In this review, we summarize the recent progress made in directing the levels and molecular pathways of these cytotoxicity-related effects by the purposeful design of NP surface charge, hydrophobicity, and combinatorial decorations.

引用

页数：22

共 161 条

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