Biomarkers in systemic sclerosis

被引：65

作者：

Castro, Susan V. ^{[1
]}

Jimenez, Sergio A. ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Jefferson Inst Mol Med, Philadelphia, PA 19107 USA

来源：

BIOMARKERS IN MEDICINE | 2010年 / 4卷 / 01期

关键词：

biomarker; endothelial cells; fibrosis; pulmonary artery hypertension; pulmonary fibrosis; scleroderma; systemic sclerosis; TGF-beta; ENDOTHELIAL GROWTH-FACTOR; PULMONARY ARTERIAL-HYPERTENSION; SOLUBLE ADHESION MOLECULES; INTERSTITIAL LUNG-DISEASE; VON-WILLEBRAND-FACTOR; COLLAGEN DEGRADATION-PRODUCTS; OLIGOMERIC MATRIX PROTEIN; IN-SITU EXPRESSION; SERUM-LEVELS; NATRIURETIC PEPTIDE;

D O I：

10.2217/BMM.09.79

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Systemic sclerosis is an autoimmune inflammatory disorder of unknown etiology characterized by pronounced fibroproliferative alterations in the microvasculature, and frequent cellular and humoral immunity abnormalities, culminating in a severe and often progressive fibrotic process. Numerous biomarkers reflecting the three main pathogenetic mechanisms in systemic sclerosis have been described; however, aside from several disease-specific autoantibodies, other biomarkers have not been thoroughly validated and require further study. Thus, there is an unmet need for validated biomarkers for diagnosis, disease classification, and evaluation of organ involvement and therapeutic response in systemic sclerosis.

引用

页码：133 / 147

页数：15

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