Concomitant Medication Use and New-Onset Diabetes Among Medicaid Beneficiaries with Chronic Obstructive Pulmonary Disease

被引:13
作者
Ajmera, Mayank [1 ]
Shen, Chan [2 ,3 ]
Sambamoorthi, Usha [4 ]
机构
[1] RTI Hlth Solut, Res Triangle Pk, NC USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Hlth Serv Res, 1400 Pressler St, Houston, TX 77030 USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Biostat, 1400 Pressler St, Houston, TX 77030 USA
[4] West Virginia Univ, Sch Pharm, Dept Pharmaceut Syst & Policy, Morgantown, WV USA
关键词
INHALED CORTICOSTEROIDS; ANTIDEPRESSANT USE; STATIN THERAPY; RISK; METAANALYSIS; MELLITUS; COPD; PREVENTION; CARE; DEPRESSION;
D O I
10.1089/pop.2016.0047
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Use of multiple prescription medications is common among individuals with chronic obstructive pulmonary disease (COPD) because of coexisting inflammatory-related conditions. Specifically, the use of antidepressants, inhaled corticosteroids (ICSs), and statins may place individuals with COPD at high risk for new-onset diabetes. The objective was to examine the relationship between the use of antidepressants, ICSs, and statins and newonset diabetes among Medicaid beneficiaries with COPD. This study used a retrospective longitudinal cohort design using multiple years (2005-2008) of Medicaid claims for beneficiaries with newly diagnosed COPD (n = 15,287), who were diabetes free at baseline. National Drug Codes were used to determine the receipt of antidepressants, ICSs, and statins, and International Classification of Diseases, Ninth Revision, Clinical Modification codes were used to define new-onset diabetes (250.x2). Multivariable logistic regression was used to examine the adjusted relationship between medication use and new-onset diabetes. Overall, 6.3% of the study population was diagnosed with new-onset diabetes. After controlling for baseline characteristics, individuals using ICSs (adjusted odds ratio [AOR]: 1.23; 95% confidence interval [CI]: 1.07, 1.47) or statins (AOR: 1.48; 95% CI: 1.27, 1.72) had a greater risk of new-onset diabetes compared to those not given ICSs, statins, or antidepressants. Analyses using combined medication categories revealed that adults using statins in combination with both antidepressants and ICSs, or when combined with ICS, were more likely to have new-onset diabetes. These findings indicate that multiple medication use (ICSs and statins) was associated with increased rates of new-onset diabetes. Further research is warranted to understand this association.
引用
收藏
页码:224 / 232
页数:9
相关论文
共 35 条
[1]   Explaining the increased health care expenditures associated with gastroesophageal reflux disease among elderly Medicare beneficiaries with chronic obstructive pulmonary disease: a cost-decomposition analysis [J].
Ajmera, Mayank ;
Raval, Amit D. ;
Shen, Chan ;
Sambamoorthi, Usha .
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2014, 9 :339-348
[2]   Inhaled anticholinergic use and all-cause mortality among elderly Medicare beneficiaries with chronic obstructive pulmonary disease [J].
Ajmera, Mayank ;
Shen, Chan ;
Pan, Xiaoyun ;
Findley, Patricia A. ;
Rust, George ;
Sambamoorthi, Usha .
INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2013, 8 :287-294
[3]  
Anecchino Caterina, 2007, Int J Chron Obstruct Pulmon Dis, V2, P567
[4]   Antidepressant use and new-onset diabetes: a systematic review and meta-analysis [J].
Bhattacharjee, Sandipan ;
Bhattacharya, Rituparna ;
Kelley, George A. ;
Sambamoorthi, Usha .
DIABETES-METABOLISM RESEARCH AND REVIEWS, 2013, 29 (04) :273-284
[5]   Use of antidepressants and statins and short-term risk of new-onset diabetes among high risk adults [J].
Bhattacharya, Rituparna ;
Ajmera, Mayank ;
Bhattacharjee, Sandipan ;
Sambamoorthi, Usha .
DIABETES RESEARCH AND CLINICAL PRACTICE, 2014, 105 (02) :251-260
[6]   Quantification of the risk of corticosteroid-induced diabetes mellitus among the elderly [J].
Blackburn, D ;
Hux, J ;
Mamdani, M .
JOURNAL OF GENERAL INTERNAL MEDICINE, 2002, 17 (09) :717-720
[7]   Hyperglycemia induced by acute central fluoxetine administration:: role of the central CRH system and 5-HT3 receptors [J].
Carvalho, F ;
Barros, D ;
Silva, J ;
Rezende, E ;
Soares, M ;
Fregoneze, J ;
Silva, EDE .
NEUROPEPTIDES, 2004, 38 (2-3) :98-105
[8]   Statin Use and the Risk of Incident Diabetes Mellitus: A Review of the Literature [J].
Colbert, Jillian D. ;
Stone, James A. .
CANADIAN JOURNAL OF CARDIOLOGY, 2012, 28 (05) :581-589
[9]   The validity of using ICD-9 codes and pharmacy records to identify patients with chronic obstructive pulmonary disease [J].
Cooke, Colin R. ;
Joo, Min J. ;
Anderson, Stephen M. ;
Lee, Todd A. ;
Udris, Edmunds M. ;
Johnson, Eric ;
Au, David H. .
BMC HEALTH SERVICES RESEARCH, 2011, 11
[10]   From COPD to chronic systemic inflammatory syndrome? [J].
Fabbri, Leonardo M. ;
Rabe, Klaus F. .
LANCET, 2007, 370 (9589) :797-799