The Role Of PD-1/PD-L1 Axis In Treg Development And Function: Implications For Cancer Immunotherapy

被引:184
作者
Cai, Jiajing [1 ]
Wang, Dongsheng [1 ]
Zhang, Guoyuan [1 ]
Guo, Xiaolan [1 ,2 ,3 ]
机构
[1] North Sichuan Med Coll, Dept Lab Med, Affiliated Hosp, 63 Wenhua Rd, Nanchong 637000, Sichuan, Peoples R China
[2] North Sichuan Med Coll, Dept Lab Med, 234 Fujiang Rd, Nanchong 637000, Sichuan, Peoples R China
[3] North Sichuan Med Coll, Translat Med Res Ctr, Nanchong 637000, Sichuan, Peoples R China
基金
中国国家自然科学基金;
关键词
PD-1; PD-L1; tregs; CTLA-4; combination therapy; REGULATORY T-CELLS; PD-1; BLOCKADE; NOTCH; ACTIVATION; MECHANISMS; MOLECULES; CTLA-4;
D O I
10.2147/OTT.S221340
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
During the past decade, immunotherapy targeting immune checkpoints has become an important component of the treatment paradigm for numerous malignancies, especially PD-1/PD-L1 blockade which was demonstrated to rejuvenate disabled T cells in cancer patients to achieve long-term remissions. However, the clinical outcome of PD-1/PD-L1 targeted monotherapy against solid malignancies is not satisfactory which may be related with the intricate tumor microenvironment. As a vital suppressive immunocyte in tumor microenvironment, Tregs are characterized by PD-1 and PD-L1 and demonstrated to contribute to the tumor progression. The latest studies have suggested that Tregs might be involved in the treatment of PD-1/PD-L1 blockade and PD-1/PD-L1 axis could influence Treg differentiation and function. However, the complicated relationship between PD-1/PD-L1 pathway and Tregs has not been fully clarified. Here, we explored the role of PD-1/PD-L1 axis in Treg development and function, as well as the potential mechanisms of PD-1/PD-L1 blockade resistance related with Tregs. Meanwhile, we discussed the combination therapy aimed at targeting PD-1/PD-L1 axis and Tregs, hoping to provide novel insights for the future cancer treatment.
引用
收藏
页码:8437 / 8445
页数:9
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