Ovarian Follicular Growth through Intermittent Vaginal Gonadotropin Administration in Diminished Ovarian Reserve Women

被引:2
作者
Hsu, Chao-Chin [1 ,2 ,3 ]
Hsu, Isabel [2 ]
Lee, Li-Hsuan [4 ]
Hsu, Rosie [5 ]
Hsueh, Yuan-Shuo [6 ]
Lin, Chih-Ying [7 ]
Chang, Hui Hua [7 ,8 ,9 ,10 ]
机构
[1] Taiwan United Birth Promoting Experts Fertil Clin, Tainan 710, Taiwan
[2] Natl Taiwan Univ Hosp, Dept Obstet & Gynecol, Taipei 104, Taiwan
[3] Natl Cheng Kung Univ Hosp, Dept Obstet & Gynecol, Tainan 701, Taiwan
[4] Nepean Hosp, Penrith, NSW 2750, Australia
[5] Natl Taiwan Univ Hosp, Dept Pediat, Taipei 104, Taiwan
[6] Chang Jung Christian Univ, Coll Hlth Sci, Dept Med Sci Ind, Tainan 711, Taiwan
[7] Natl Cheng Kung Univ, Coll Med, Inst Clin Pharm & Pharmaceut Sci, Tainan 701, Taiwan
[8] Natl Cheng Kung Univ, Coll Med, Sch Pharm, Tainan 701, Taiwan
[9] Natl Cheng Kung Univ, Natl Cheng Kung Univ Hosp, Coll Med, Dept Pharm, Tainan 701, Taiwan
[10] Natl Cheng Kung Univ Hosp, Dept Pharm, Dou Liou Branch, Touliu 640, Yunlin, Taiwan
关键词
gonadotropins; vaginal administration; poor ovarian response; diminished ovarian reserve; POSEIDON group; controlled ovarian hyperstimulation; in vitro fertilization; IN-VITRO FERTILIZATION; STIMULATING-HORMONE; DRUG-DELIVERY; LUTEAL-PHASE; IVF; PROGESTERONE; PHARMACOKINETICS; INJECTION; EFFICACY; ROUTE;
D O I
10.3390/pharmaceutics14040869
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
It is a challenge to obtain enough oocytes during in vitro fertilization (IVF) in women who have a poor ovarian response (POR) in achieving conception. We have adopted the characteristics of the first uterine pass effect, which we pioneered in employing the vaginal administration of gonadotropins in women receiving IVF treatments. In our previous study employing vaginal administration, faster absorption and slower elimination of gonadotropins were demonstrated, and, female subjects presented proper ovarian follicle growth and pregnancy rates. In this study, during 2016-2020, 300 to 675 IU of gonadotropins were administered vaginally every three days in 266 POR women for their controlled ovarian hyperstimulation (COH). The injections were performed with needles angled at 15-30 degrees towards the middle-upper portions of the bilateral vaginal wall, with an injection depth of 1-2 mm. For the COH results, these women, on average, received 3.0 +/- 0.9 vaginal injections and a total dose of 1318.4 +/- 634.4 IU gonadotropins, resulting in 2.2 +/- 1.9 mature oocytes and 1.0 +/- 1.2 good embryos. Among these embryos, 0.9 +/- 1.0 were transferred to reach a clinical pregnancy rate of 18.1% and a live birth rate of 16.7%. In conclusion, the intermittent vaginal administration of gonadotropins proved to be effective in POR women for their IVF treatments.
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页数:16
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