Role of transforming growth factor β in conjunctival scarring

被引：53
作者：
Cordeiro, MF
机构：
[1] Moorfields Eye Hosp, Dept Pathol, London EC1V 9EL, England
[2] Inst Ophthalmol, London EC1V 9EL, England
[3] Moorfields Eye Hosp, Dept Glaucoma, London EC1V 9EL, England
来源：
CLINICAL SCIENCE | 2003年 / 104卷 / 02期
关键词：
anti-scarring therapy; conjunctival scarring; glaucoma; transforming growth factor beta;
D O I：
10.1042/CS20020150
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Glaucoma is the major cause of irreversible blindness throughout the world. Of all of the treatments that are available at present, the most effective appears to be surgery; however, excessive conjunctival scarring can lead to surgical failure. In the last decade, the introduction of the anti-metabolites mitomycin-C and 5-fluorouracil as anti-scarring treatments have greatly improved the results of glaucoma surgery, but these agents are associated with complications that can potentially result in blindness. A possible target for a more physiological approach to anti-scarring is transforming growth factor beta. This review examines the role of transforming growth factor beta in conjunctival scarring and discusses promising new ways of modifying its activity.
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收藏
页码：181 / 187
页数：7
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