Circulating Tumor Cells in Prostate Cancer Diagnosis and Monitoring: An Appraisal of Clinical Potential

被引:45
作者
Galletti, Giuseppe [1 ,2 ]
Portella, Luigi [1 ,2 ]
Tagawa, Scott T. [1 ,2 ]
Kirby, Brian J. [1 ,2 ,3 ]
Giannakakou, Paraskevi [1 ,2 ]
Nanus, David M. [1 ,2 ]
机构
[1] Weill Cornell Med Coll, Div Hematol & Med Oncol, New York, NY 10021 USA
[2] Weill Cornell Med Coll, Weill Cornell Canc Ctr, New York, NY 10021 USA
[3] Cornell Univ, Sibley Sch Mech & Aerosp Engn, Ithaca, NY 14853 USA
关键词
MITOXANTRONE PLUS PREDNISONE; ANDROGEN RECEPTOR; PERIPHERAL-BLOOD; BREAST-CANCER; ANTITUMOR-ACTIVITY; INCREASED SURVIVAL; PREDICT SURVIVAL; END-POINTS; ANTIGEN; EXPRESSION;
D O I
10.1007/s40291-014-0101-8
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Circulating tumor cells (CTCs) have emerged as a viable solution to the lack of tumor tissue availability for patients with a variety of solid tumors, including prostate cancer. Different approaches have been used to capture this tumor cell population and several of these techniques have been used to assess the potential role of CTCs as a biological marker to predict treatment efficacy and clinical outcome. CTCs are now considered a strong tool to understand the molecular characteristics of prostate cancer, and to be used and analyzed as a 'liquid biopsy' in the attempt to grasp the biological portrait of the disease in the individual patient.
引用
收藏
页码:389 / 402
页数:14
相关论文
共 103 条
  • [1] Detection of circulating prostate-specific antigen-secreting cells in prostate cancer patients
    Alix-Panabières, C
    Rebillard, X
    Brouillet, JP
    Barbotte, E
    Iborra, F
    Segui, B
    Maudelonde, T
    Jolivet-Reynaud, C
    Vendrell, JP
    [J]. CLINICAL CHEMISTRY, 2005, 51 (08) : 1538 - 1541
  • [2] Characterization and enumeration of cells secreting tumor markers in the peripheral blood of breast cancer patients
    Alix-Panabières, C
    Brouillet, JP
    Fabbro, M
    Yssel, H
    Rousset, T
    Maudelonde, T
    Choquet-Kastylevsky, G
    Vendrell, JP
    [J]. JOURNAL OF IMMUNOLOGICAL METHODS, 2005, 299 (1-2) : 177 - 188
  • [3] Detection and characterization of putative metastatic precursor cells in cancer patients
    Alix-Panabieres, Catherine
    Vendrell, Jean-Pierre
    Pelle, Olivier
    Rebillard, Xavier
    Riethdorf, Sabine
    Mueller, Volkmar
    Fabbro, Michel
    Pantel, Klaus
    [J]. CLINICAL CHEMISTRY, 2007, 53 (03) : 537 - 539
  • [4] Full-length cytokeratin-19 is released by human tumor cells: a potential role in metastatic progression of breast cancer
    Alix-Panabieres, Catherine
    Vendrell, Jean-Pierre
    Slijper, Monique
    Pelle, Olivier
    Barbotte, Eric
    Mercier, Gregoire
    Jacot, William
    Fabbro, Michel
    Pantel, Klaus
    [J]. BREAST CANCER RESEARCH, 2009, 11 (03):
  • [5] Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases
    Allard, WJ
    Matera, J
    Miller, MC
    Repollet, M
    Connelly, MC
    Rao, C
    Tibbe, AGJ
    Uhr, JW
    Terstappen, LWMM
    [J]. CLINICAL CANCER RESEARCH, 2004, 10 (20) : 6897 - 6904
  • [6] Anand A, 2010, ASCO ANN M
  • [7] Mortality Results from a Randomized Prostate-Cancer Screening Trial
    Andriole, Gerald L.
    Grubb, Robert L., III
    Buys, Saundra S.
    Chia, David
    Church, Timothy R.
    Fouad, Mona N.
    Gelmann, Edward P.
    Kvale, Paul A.
    Reding, Douglas J.
    Weissfeld, Joel L.
    Yokochi, Lance A.
    Crawford, E. David
    O'Brien, Barbara
    Clapp, Jonathan D.
    Rathmell, Joshua M.
    Riley, Thomas L.
    Hayes, Richard B.
    Kramer, Barnett S.
    Izmirlian, Grant
    Miller, Anthony B.
    Pinsky, Paul F.
    Prorok, Philip C.
    Gohagan, John K.
    Berg, Christine D.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (13) : 1310 - 1319
  • [8] [Anonymous], UROL ONCOL
  • [9] Antonarakis ES, 2013, ASCO ANN M
  • [10] Prostate-specific antigen and pain surrogacy analysis in metastatic hormone-refractory prostate cancer
    Armstrong, Andrew J.
    Garrett-Mayer, Elizabeth
    Yang, Yi-Chun Ou
    Carducci, Michael A.
    Tannock, Ian
    de Wit, Ronald
    Eisenberger, Mario
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (25) : 3965 - 3970