The phosphatidylinositol 3-kinase-AKT pathway in human cancer

被引：5020
作者：
Vivanco, I
Sawyers, CL
机构：
[1] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Sch Med, Dept Urol, Los Angeles, CA 90095 USA
[4] Univ Calif Los Angeles, Sch Med, Inst Mol Biol, Los Angeles, CA 90095 USA
来源：
NATURE REVIEWS CANCER | 2002年 / 2卷 / 07期
关键词：
D O I：
10.1038/nrc839
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
One signal that is overactivated in a wide range of tumour types is the production of a phospholipid, phosphatidylinositol (3,4,5) trisphosphate, by phosphatidylinositol 3-kinase PI3N. This lipid and the protein kinase that is activated by it - AKT - trigger a cascade of responses, from cell growth and proliferation to survival and motility, that drive tumour progression. Small-molecule therapeutics that block PI3K signalling might deal a severe blow-to cancer cells by blocking many aspects of the tumour-cell phenotype.
引用
收藏
页码：489 / 501
页数：13
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