The phosphatidylinositol 3-kinase-AKT pathway in human cancer

被引：5020

作者：

Vivanco, I

Sawyers, CL

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Med, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Med, Dept Mol & Med Pharmacol, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Sch Med, Dept Urol, Los Angeles, CA 90095 USA

[4] Univ Calif Los Angeles, Sch Med, Inst Mol Biol, Los Angeles, CA 90095 USA

来源：

NATURE REVIEWS CANCER | 2002年 / 2卷 / 07期

关键词：

D O I：

10.1038/nrc839

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One signal that is overactivated in a wide range of tumour types is the production of a phospholipid, phosphatidylinositol (3,4,5) trisphosphate, by phosphatidylinositol 3-kinase PI3N. This lipid and the protein kinase that is activated by it - AKT - trigger a cascade of responses, from cell growth and proliferation to survival and motility, that drive tumour progression. Small-molecule therapeutics that block PI3K signalling might deal a severe blow-to cancer cells by blocking many aspects of the tumour-cell phenotype.

引用

页码：489 / 501

页数：13

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