Dual neurocircuitry dysfunctions in disruptive behavior disorders: emotional responding and response inhibition

被引：67

作者：

Hwang, S. ^{[1
]}

Nolan, Z. T. ^{[2
]}

White, S. F. ^{[3
]}

Williams, W. C. ^{[4
]}

Sinclair, S. ^{[5
]}

Blair, R. J. R. ^{[5
]}

机构：

[1] Univ Nebraska Med Ctr, Omaha, NE 68198 USA

[2] Penn State Coll Med, MD PhD Program, Hershey, PA USA

[3] Boystown Natl Res Hosp, Boystown, NE USA

[4] Stanford Univ, Dept Psychol, Stanford, CA USA

[5] NIMH, Dept Hlth & Human Serv, Sect Affect Cognit Neurosci, NIH, Bethesda, MD 20892 USA

来源：

PSYCHOLOGICAL MEDICINE | 2016年 / 46卷 / 07期

基金：

美国国家卫生研究院;

关键词：

Amygdala; callous-unemotional trait; disruptive behavior disorder; emotional responding; response inhibition; CALLOUS-UNEMOTIONAL TRAITS; CONDUCT PROBLEMS; PSYCHOPATHIC TRAITS; AMYGDALA RESPONSE; NEURAL RESPONSES; EXPECTED VALUE; CHILDREN; YOUTHS; CONNECTIVITY; ADOLESCENTS;

D O I：

10.1017/S0033291716000118

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Background. To determine the functional integrity of the neural systems involved in emotional responding/regulation and response control/inhibition in youth (age 10-18 years) with disruptive behavioral disorders (DBDs: conduct disorder and/or oppositional defiant disorder) as a function of callous-unemotional (CU) traits. Method. Twenty-eight healthy youths and 35 youths with DBD [high CU (HCU), n = 18; low CU (LCU), n = 17] performed the fMRI Affective Stroop task. Participants viewed positive, neutral, and negative images under varying levels of cognitive load. A 3-way ANOVA (groupxemotion by task) was conducted on the BOLD response data. Results. Youth with DBD-HCU showed significantly less activation of ventromedial prefrontal cortex (vmPFC) and amygdala in response to negative stimuli, compared to healthy youth and youth with DBD-LCU. vmPFC responsiveness was inversely related to CU symptoms in DBD. Youth with DBD-LCU showed decreased functional connectivity between amygdala and regions including inferior frontal gyrus in response to emotional stimuli. Youth with DBD (LCU and HCU) additionally showed decreased insula responsiveness to high load (incongruent trials) compared to healthy youth. Insula responsiveness was inversely related to ADHD symptoms in DBD. Conclusions. These data reveal two forms of pathophysiology in DBD. One associated with reduced amygdala and vmPFC responses to negative stimuli and related to increased CU traits. Another associated with reduced insula responses during high load task trials and related to ADHD symptoms. Appropriate treatment will need to be individualized according to the patient's specific pathophysiology.

引用

页码：1485 / 1496

页数：12

共 58 条

[1]

[Anonymous], 2005, Technical report

[2]

APA, 2013, DIAGN STAT MAN 5, V5

[3] Neuroimaging findings in disruptive behavior disorders [J].