Lead, mercury, and cadmium in umbilical cord serum and birth outcomes in Chinese fish consumers

被引:28
作者
Tang, Mengling [1 ]
Xu, Chenye [1 ]
Lin, Nan [1 ]
Liu, Kai [2 ]
Zhang, Yongli [3 ]
Yu, Xinwei [3 ]
Liu, Weiping [1 ]
机构
[1] Zhejiang Univ, Coll Environm & Resource Sci, Key Lab Environm Remediat & Ecosyst Hlth, Minist Educ, Hangzhou 310058, Zhejiang, Peoples R China
[2] Tsinghua Univ, Sch Environm, POPs Res Ctr, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China
[3] Key Lab Hlth Risk Factors Seafood Zhejiang Prov, Zhoushan Municipal Dis Control & Prevent, Zhoushan 316000, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
Lead; Mercury; Cadmium; Birth outcomes; Fish consumers; HUMAN PLACENTA; PRENATAL EXPOSURE; PREGNANT-WOMEN; TRACE-ELEMENTS; HEAVY-METALS; BLOOD; FETAL; LEVEL; WEIGHT; CHILD;
D O I
10.1016/j.chemosphere.2016.01.058
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Heavy metals such as lead (Pb), mercury (Hg), and cadmium (Cd) were detected in the islands of Yangtze River estuary and Hangzhou bay and their exposure caused potential health risk for the residents. To assess the exposure levels of Pb, Hg, and Cd, the umbilical cord serum samples were collected from 103 mother-newborn pairs as the noninvasive specimens. The association of the concentration of Pb, Hg, and Cd with the birth outcomes was evaluated. Pb, Hg, and Cd had high exposure levels with the median concentrations at 76.20 mu g L-1 [interquartile range (IQR): 44.71, 115.80], 21.94 mu g L-1 (IQR: 15.10, 27.64), and 6.36 mu g L-1 (IQR: 3.63, 13.34), respectively. A unit increase in the Pb umbilical cord serum concentration (mu g L-1) was significantly associated with a 0.29 cm (95% CI: -0.50, -0.09) decrease in birth height and a 0.22 cm (95%CI: -0.44, 0.00) decrease in head circumference. The middle tertile Pb and Hg exposure levels were found significantly negative effects on birth outcomes compared with low tertile exposure levels. Exposure to Cd showed no apparent effect on birth outcomes. Our results suggested that Pb and Hg exposure has potential adverse effects on birth outcomes in Chinese fish consumers from Yangtze River outlet and Hangzhou bay estuary regions. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:270 / 275
页数:6
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