An Update on Clostridioides difficile Binary Toxin

被引：32
作者：
Martinez-Melendez, Adrian [1 ]
Cruz-Lopez, Flora [1 ]
Morfin-Otero, Rayo [2 ]
Maldonado-Garza, Hector J. [3 ]
Garza-Gonzalez, Elvira [4 ,5 ]
机构：
[1] Univ Autonoma Nuevo Leon, Fac Ciencias Quim, Subdirecc Acad Quim Farmaceut Biol, Pedro Alba S-N, San Nicolas De Los Garza 66450, Nuevo Leon, Mexico
[2] Univ Guadalajara, Ctr Univ Ciencias Salud, Inst Patol Infecciosa & Expt Dr Francisco Ruiz Sa, Calle Hosp 308, Guadalajara 44280, Jalisco, Mexico
[3] Univ Autonoma Nuevo Leon, Hosp Univ Dr Jose Eleuterio Gonzalez, Fac Med, Serv Gastroenterol, Av Francisco I Madero Pte S-N & Av Jose E Gonzale, Monterrey 64460, Nuevo Leon, Mexico
[4] Univ Autonoma Nuevo Leon, Fac Med, Dept Bioquim & Med Mol, Av Francisco I Madero Pte S-N & Av Jose E Gonzale, Monterrey 64460, Nuevo Leon, Mexico
[5] Univ Autonoma Nuevo Leon, Hosp Univ Dr Jose Eleuterio Gonzalez, Av Francisco I Madero Pte S-N & Av Jose E Gonzale, Monterrey 64460, Nuevo Leon, Mexico
来源：
TOXINS | 2022年 / 14卷 / 05期
关键词：
Clostridioides difficile; binary toxin; epidemiology; hypervirulent strains; EMERGING STRAIN; MEMBRANE TRANSLOCATION; RIBOTYPE; 078; INFECTION; EMERGENCE; DIAGNOSIS; EPIDEMIC; CDT; AMERICA; IMMUNOASSAY;
D O I：
10.3390/toxins14050305
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Infection with Clostridioides difficile (CDI), a common healthcare-associated infection, includes symptoms ranging from mild diarrhea to severe cases of pseudomembranous colitis. Toxin A (TcdA) and toxin B (TcdB) cause cytotoxicity and cellular detachment from intestinal epithelium and are responsible for CDI symptomatology. Approximately 20% of C. difficile strains produce a binary toxin (CDT) encoded by the tcdA and tcdB genes, which is thought to enhance TcdA and TcdB toxicity; however, the role of CDT in CDI remains controversial. Here, we focused on describing the main features of CDT and its impact on the host, clinical relevance, epidemiology, and potential therapeutic approaches.
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页数：13
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