An Update on Clostridioides difficile Binary Toxin

被引：32
作者：
Martinez-Melendez, Adrian [1 ]
Cruz-Lopez, Flora [1 ]
Morfin-Otero, Rayo [2 ]
Maldonado-Garza, Hector J. [3 ]
Garza-Gonzalez, Elvira [4 ,5 ]
机构：
[1] Univ Autonoma Nuevo Leon, Fac Ciencias Quim, Subdirecc Acad Quim Farmaceut Biol, Pedro Alba S-N, San Nicolas De Los Garza 66450, Nuevo Leon, Mexico
[2] Univ Guadalajara, Ctr Univ Ciencias Salud, Inst Patol Infecciosa & Expt Dr Francisco Ruiz Sa, Calle Hosp 308, Guadalajara 44280, Jalisco, Mexico
[3] Univ Autonoma Nuevo Leon, Hosp Univ Dr Jose Eleuterio Gonzalez, Fac Med, Serv Gastroenterol, Av Francisco I Madero Pte S-N & Av Jose E Gonzale, Monterrey 64460, Nuevo Leon, Mexico
[4] Univ Autonoma Nuevo Leon, Fac Med, Dept Bioquim & Med Mol, Av Francisco I Madero Pte S-N & Av Jose E Gonzale, Monterrey 64460, Nuevo Leon, Mexico
[5] Univ Autonoma Nuevo Leon, Hosp Univ Dr Jose Eleuterio Gonzalez, Av Francisco I Madero Pte S-N & Av Jose E Gonzale, Monterrey 64460, Nuevo Leon, Mexico
来源：
TOXINS | 2022年 / 14卷 / 05期
关键词：
Clostridioides difficile; binary toxin; epidemiology; hypervirulent strains; EMERGING STRAIN; MEMBRANE TRANSLOCATION; RIBOTYPE; 078; INFECTION; EMERGENCE; DIAGNOSIS; EPIDEMIC; CDT; AMERICA; IMMUNOASSAY;
D O I：
10.3390/toxins14050305
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Infection with Clostridioides difficile (CDI), a common healthcare-associated infection, includes symptoms ranging from mild diarrhea to severe cases of pseudomembranous colitis. Toxin A (TcdA) and toxin B (TcdB) cause cytotoxicity and cellular detachment from intestinal epithelium and are responsible for CDI symptomatology. Approximately 20% of C. difficile strains produce a binary toxin (CDT) encoded by the tcdA and tcdB genes, which is thought to enhance TcdA and TcdB toxicity; however, the role of CDT in CDI remains controversial. Here, we focused on describing the main features of CDT and its impact on the host, clinical relevance, epidemiology, and potential therapeutic approaches.
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页数：13
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共 105 条
  • [1] The Importance of Therapeutically Targeting the Binary Toxin from Clostridioides difficile
    Abeyawardhane, Dinendra L.
    Godoy-Ruiz, Raquel
    Adipietro, Kaylin A.
    Varney, Kristen M.
    Rustandi, Richard R.
    Pozharski, Edwin
    Weber, David J.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (06) : 1 - 12
  • [2] Clostridium difficile colitis: pathogenesis and host defence
    Abt, Michael C.
    McKenney, Peter T.
    Pamer, Eric G.
    [J]. NATURE REVIEWS MICROBIOLOGY, 2016, 14 (10) : 609 - 620
  • [3] Clostridium difficile Toxin Biology
    Aktories, Klaus
    Schwan, Carsten
    Jank, Thomas
    [J]. ANNUAL REVIEW OF MICROBIOLOGY, VOL 71, 2017, 71 : 281 - 307
  • [4] Structural insights into the transition of Clostridioides difficile binary toxin from prepore to pore
    Anderson, David M.
    Sheedlo, Michael J.
    Jensen, Jaime L.
    Lacy, D. Borden
    [J]. NATURE MICROBIOLOGY, 2020, 5 (01) : 102 - +
  • [5] In silico, in vitro and in vivo analysis of putative virulence factors identified in large clostridial toxin-negative, binary toxin- producing C. difficile strains
    Androga, G. O.
    Knight, D. R.
    Hutton, M. L.
    Mileto, S. J.
    James, M. L.
    Evans, C.
    Lyras, D.
    Chang, B. J.
    Foster, N. F.
    Riley, T. V.
    [J]. ANAEROBE, 2019, 60
  • [6] Antimicrobial resistance in large clostridial toxin-negative, binary toxin-positive Clostridium difficile ribotypes
    Androga, Grace O.
    Knight, Daniel R.
    Lim, Su-Chen
    Foster, Niki E.
    Riley, Thomas V.
    [J]. ANAEROBE, 2018, 54 : 55 - 60
  • [7] Infection with Toxin A-Negative, Toxin B-Negative, Binary Toxin-Positive Clostridium difficile in a Young Patient with Ulcerative Colitis
    Androga, Grace O.
    Hart, Julie
    Foster, Niki F.
    Charles, Adrian
    Forbes, David
    Riley, Thomas V.
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2015, 53 (11) : 3702 - 3704
  • [8] Evaluation of the Cepheid Xpert C. difficile/Epi and Meridian Bioscience illumigene C. difficile Assays for Detecting Clostridium difficile Ribotype 033 Strains
    Androga, Grace O.
    McGovern, Alan M.
    Elliott, Briony
    Chang, Barbara J.
    Perkins, Timothy T.
    Foster, Niki F.
    Riley, Thomas V.
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 2015, 53 (03) : 973 - 975
  • [9] Bacci S, 2011, EMERG INFECT DIS, V17, P976, DOI [10.3201/eid1706.101483, 10.3201/eid/1706.101483]
  • [10] Diagnosis and Treatment of Clostridium difficile in Adults A Systematic Review
    Bagdasarian, Natasha
    Rao, Krishna
    Malani, Preeti N.
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2015, 313 (04): : 398 - 408
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