SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION OF SOME NEW 2-(3-PYRIDIL)-THIAZOLYL-1,3,4-OXADIAZOLINES

被引：0

作者：

Oniga, Smaranda Dafina ^{[1
]}

Araniciu, Catalin ^{[1
]}

Stoica, Cristina Ioana ^{[1
]}

Palage, Mariana Doina ^{[1
]}

Vlase, Laurian ^{[2
]}

Pirnau, Adrian ^{[3
]}

Marutescu, Luminita ^{[4
,5
]}

Chifiriuc, Mariana Carmen ^{[4
,5
]}

Oniga, Ovidiu ^{[6
]}

机构：

[1] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Therapeut Chem, 12 Ion Creanga St, Cluj Napoca 400010, Romania

[2] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmaceut Technol & Biopharm, 41 Victor Babes St, Cluj Napoca 400012, Romania

[3] Natl Inst Res & Dev Isotop & Mol Technol, 65-103 Donat St, Cluj Napoca 400293, Romania

[4] Univ Bucharest, Fac Biol, Dept Microbiol, 1-3 Portocalelor St, Bucharest 60101, Romania

[5] Univ Bucharest, Res Inst, ICUB, 91-95 Independentei St, Bucharest, Romania

[6] Iuliu Hatieganu Univ Med & Pharm, Fac Pharm, Dept Pharmaceut Chem, 41 Victor Babes St, Cluj Napoca 400012, Romania

来源：

FARMACIA | 2017年 / 65卷 / 04期

关键词：

thiazole; oxadiazoline; antimicrobial activity; DERIVATIVES; CHALLENGES;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A new series of 4-methyl-2-(pyridin-3-yI)-thiazole-5-yl-oxadiazolines were synthesized starting from 4-methy1-2-(pyridin-3-yl)thiazole-5-carbohydrazide. The newly synthesized compounds were characterized by analytical H-1-NMR, C-13-NMR and mass spectral data. These compounds were screened for their antimicrobial activity against Gram-positive and Gram-negative bacterial strains and one fungal strain (Candida albicans).

引用

页码：501 / 507

页数：7

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