Regioselective (site-selective) functionalisation of unsaturated halogenated nitrogen, oxygen and sulfur heterocycles by Pd-catalysed cross-couplings and direct arylation processes

被引:362
作者
Fairlamb, Ian J. S. [1 ]
机构
[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England
关键词
D O I
10.1039/b611177g
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
This tutorial review focuses on several practical synthetic transformations utilising palladium catalysis that facilitate the synthesis of functionalised unsaturated heterocycles in a regioselective ( site-selective) manner. Cross-couplings of electron-deficient, electron-neutral and electron-rich unsaturated halogenated heterocycles with various organometallic reagents, and other types of nucleophiles, are detailed. Direct arylation of electron-rich unsaturated heterocyclic compounds by C - H functionalisation is also presented.
引用
收藏
页码:1036 / 1045
页数:10
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