HIV;
cardiomyopathy;
dementia;
nephropathy;
bone marrow abnormalities;
enteropathy;
cytokines;
chemokines;
highly active antiretroviral therapy;
D O I:
10.1097/00002030-200304001-00008
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Evidence derived from numerous studies supports a primary role for HIV in the development of direct damage of different organs eventually being responsible for the appearance of dementia, cardiomyopathy, nephropathy and hematologic abnormalities. As a result of the introduction of effective antiretroviral combination therapies a dramatic decrease of AIDS-associated opportunistic infections and malignancies was observed; however, the role of HAART on HIV organ damage is less well appreciated. In this review we discuss the most common HIV-associated diseases, their pathogenesis as well as the possible changing scenery in the HAARTera. (C) 2003 Lippincott Williams Wilkins.