HIV and direct damage of organs: disease spectrum before and during the highly active antiretroviral therapy era

被引:17
作者
Moroni, M
Antinori, S
机构
[1] Univ Palermo, Inst Infect Pathol & Virol, I-90184 Palermo, Italy
[2] Univ Palermo, Inst Infect Pathol & Virol, I-90133 Palermo, Italy
关键词
HIV; cardiomyopathy; dementia; nephropathy; bone marrow abnormalities; enteropathy; cytokines; chemokines; highly active antiretroviral therapy;
D O I
10.1097/00002030-200304001-00008
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Evidence derived from numerous studies supports a primary role for HIV in the development of direct damage of different organs eventually being responsible for the appearance of dementia, cardiomyopathy, nephropathy and hematologic abnormalities. As a result of the introduction of effective antiretroviral combination therapies a dramatic decrease of AIDS-associated opportunistic infections and malignancies was observed; however, the role of HAART on HIV organ damage is less well appreciated. In this review we discuss the most common HIV-associated diseases, their pathogenesis as well as the possible changing scenery in the HAARTera. (C) 2003 Lippincott Williams Wilkins.
引用
收藏
页码:S51 / S64
页数:14
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