The genome sequence of the SARS-associated coronavirus

被引：1589

作者：

Marra, MA

Jones, SJM

Astell, CR

Holt, RA

Brooks-Wilson, A

Butterfield, YSN

Khattra, J

Asano, JK

Barber, SA

Chan, SY

Cloutier, A

Coughlin, SM

Freeman, D

Girn, N

Griffith, OL

Leach, SR

Mayo, M

McDonald, H

Montgomery, SB

Pandoh, PK

Petrescu, AS

Robertson, AG

Schein, JE

Siddiqui, A

Smailus, DE

Stott, JE

Yang, GS

Plummer, F

Andonov, A

Artsob, H

Bastien, N

Bernard, K

Booth, TF

Bowness, D

Czub, M

Drebot, M

Fernando, L

Flick, R

Garbutt, M

Gray, M

Grolla, A

Jones, S

Feldmann, H

Meyers, A

Kabani, A

Li, Y

Normand, S

Stroher, U

Tipples, GA

Tyler, S

机构：

[1] British Columbia Canc Agcy, Genome Sci Ctr, Vancouver, BC V5Z 4E6, Canada

[2] Natl Microbiol Lab, Winnipeg, MB R3E 3R2, Canada

[3] British Columbia Ctr Dis Control, Vancouver, BC V5Z 4R4, Canada

[4] Univ British Columbia, Ctr Dis Control, Vancouver, BC V5Z 4R4, Canada

[5] Univ Victoria, Dept Biochem & Microbiol, Victoria, BC V8W 3P6, Canada

来源：

SCIENCE | 2003年 / 300卷 / 5624期

关键词：

D O I：

10.1126/science.1085953

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We sequenced the 29,751-base genome of the severe acute respiratory syndrome (SARS)-associated coronavirus known as the Tor2 isolate. The genome sequence reveals that this coronavirus is only moderately related to other known coronaviruses, including two human coronaviruses, HCoV-OC43 and HCoV-229E. Phylogenetic analysis of the predicted viral proteins indicates that the virus does not closely resemble any of the three previously known groups of coronaviruses. The genome sequence will aid in the diagnosis of SARS virus infection in humans and potential animal hosts (using polymerase chain reaction and immunological tests), in the development of antivirals (including neutralizing antibodies), and in the identification of putative epitopes for vaccine development.

引用

页码：1399 / 1404

页数：7

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